ToolsFunding ledger · 86 papers
By Jose Pollman·Updated 23 September 2026
Who paid for the trial?
Every human trial, systematic review and guideline this site relies on, one row per paper, with the funding statement and the authors’ declared interests quoted from the paper. Nothing summarised, nothing characterised.
This is the standing record behind every “who paid” sentence on the site: the papers we cite, with what each one says about its own money. Every statement is quoted, not summarised, so what you read here is what the authors wrote, down to the punctuation. A manufacturer paying for a trial does not make the trial wrong; it is context the reader is entitled to see next to the finding, which is the rule set out in how we review.
none declared = the paper says it had no funding; not stated = the paper says nothing we could read; manufacturer-employed authors = a funding line, an interests line or the PubMed affiliation names the maker as an author’s employer (the basis is shown in the row).
The table is wider than the page. Scroll it sideways, or use the arrows; the funding and interests columns are to the right.
| n / duration | Funding statement, verbatim | Competing interests, verbatim | Used on | |||||
|---|---|---|---|---|---|---|---|---|
| Enamel damage from tooth-whitening- a systematic review and meta-analysisMárton P, 2026, J DentDOI PubMed Statement sourceLedger id MARTON2026 | meta-analysis | whitening | 81 eligible laboratory studies; 9 pooled — | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Prosthodontics, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Oral Biology, Faculty of Dentistry Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Prosthodontics, Semmelweis University, Budapest, Hungary. Electronic address: abram.emese@semmelweis.hu. (record) | meta-analysis · whitening · 81 eligible laboratory studies; 9 pooled · not stated · basis: none available | not stated not statedbasis: none available | do-whitening-strips-damage-enamel |
| The effects of using water flosser versus interdental brush on gingival health in patients with mandibular bonded retainer — a randomized controlled trialMasood Z, 2026, BMC Oral HealthDOI Statement sourceLedger id MASOOD2026 | RCT | water flosser | — 6 months | Funding: "Department of Surgery, Aga Khan University Hospital, Karachi." Acknowledgements: "We would like to acknowledge department of surgery, Aga Khan University Hospital, for funding the study."Read on 2026-09-16 at the statement source | "The authors declare no competing interests." | RCT · water flosser · — / 6 months · public/charity · basis: funding statement | public/charity Aga Khan University Hospital, Department of Surgerybasis: funding statement | not yet cited |
| Impact of sugar consumption on dental caries in children and adolescents: a systematic review of frequency versus quantityPombo-Lopes J, 2026, BMC Public HealthDOI PubMed Statement sourceLedger id SUG2026 | systematic review | sugar | 37 studies, 59,383 participants — | "This work was supported by FCT - Fundação para a Ciência e Tecnologia, I.P. by project reference UID/4585/2025 and DOI identifier https://doi.org/10.54499/UID/04585/2025."Read on 2026-09-15 at the statement source | "The authors declare no competing interests." | systematic review · sugar · 37 studies, 59,383 participants · public/charity · basis: funding statement | public/charity FCT - Fundação para a Ciência e Tecnologia (Portugal)basis: funding statement | can-teeth-remineralise |
| Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternativesWong AJ, 2026, Eur J PediatrDOI PubMed Statement sourceLedger id WONG2026 | systematic review | hydroxyapatite | 122 studies, 20 with direct paediatric evidence — | "No external funding was received to support this work."Read on 2026-09-16 at the statement source | "The authors declare no competing interests." | systematic review · hydroxyapatite · 122 studies, 20 with direct paediatric evidence · none declared · basis: funding statement | none declared none declaredbasis: funding statement | do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpastehydroxyapatite-vs-fluoride-for-kids |
| Oral irrigator versus dental floss in orthodontic patients: a systematic review and meta-analysisYiamwattana I, 2026, Int J Dent HygDOI PubMed Statement sourceLedger id YIAM2026 | meta-analysis | water flosser | 4 trials — | No funding statement in the paperRead on 2026-09-16 at the statement source | "The authors declare no conflicts of interest." | meta-analysis · water flosser · 4 trials · not stated · basis: none available | not stated not statedbasis: none available | not yet cited |
| Clinical and biochemical evaluation of oral irrigator effectiveness in fixed orthodontic treatment: a randomised clinical trialŞahin E, 2026, Int J Dent HygDOI PubMed Statement sourceLedger id SAHIN2026 | RCT | water flosser | 30 patients 8 weeks | Research funding: "Ondokuz Mayis Üniversitesi. Grant Number: PYO.DIŞ.1904.18.006"Read on 2026-09-16 at the statement source | "The authors declare no conflicts of interest." | RCT · water flosser · 30 patients / 8 weeks · public/charity · basis: funding statement | public/charity Ondokuz Mayis Universitybasis: funding statement | not yet cited |
| Hydrogen Peroxide-Free Color Correctors for Tooth Whitening in Adolescents and Young Adults: A Systematic Review of In Vitro and Clinical EvidenceBoruga M, 2025, Dent J (Basel)DOI PubMed Statement sourceLedger id BORUGA2025 | systematic review | whitening | 6 studies: 1 clinical trial, 5 laboratory — | Funding: "The article processing charge was paid by the “Victor Babes” University of Medicine and Pharmacy Timisoara."Read on 2026-09-23 at the statement source | Conflicts of Interest: "The authors declare no conflicts of interest." | systematic review · whitening · 6 studies: 1 clinical trial, 5 laboratory · public/charity · basis: funding statement | public/charity “Victor Babes” University of Medicine and Pharmacy Timisoara (article processing charge)basis: funding statement | do-whitening-strips-damage-enamel |
| The role of hydroxyapatite-based, fluoride-free toothpastes on the prevention and the remineralization of initial caries lesions: a systematic review and meta-analysisChatzidimitriou K, 2025, J DentDOI PubMed Statement sourceLedger id CHATZ2025 | meta-analysis | hydroxyapatite | 4 of 68 retrieved studies — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled) | meta-analysis · hydroxyapatite · 4 of 68 retrieved studies · not stated · basis: none available | not stated not statedbasis: none available | do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpastehydroxyapatite-vs-fluoride-for-kids |
| Do we have enough evidence to recommend hydroxyapatite toothpaste for preventing dental caries?Gugnani N, 2025, Evid Based DentDOI PubMed Statement sourceLedger id GUG2025 | commentary | hydroxyapatite | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled) | commentary · hydroxyapatite · — · not stated · basis: none available | not stated not statedbasis: none available | hydroxyapatite-toothpaste |
| Systematic Review of Experimental Gingivitis Induction Methods: Methodological Variations and Their Impact on Inflammation ProgressionJamjoom AG, 2025, Patient Prefer AdherenceDOI PubMed Statement sourceLedger id EG2025 | systematic review | gingivitis | 10 studies induction periods of 9 to 28 days | "This research received no external funding."Read on 2026-09-15 at the statement source | "The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest." | systematic review · gingivitis · 10 studies / induction periods of 9 to 28 days · none declared · basis: funding statement | none declared none declaredbasis: funding statement | gum-disease-signs |
| Efficacy of a water flosser compared to an interdental brush on gingival bleeding and gingival abrasion: a 4 week randomized controlled trialMancinelli-Lyle D, 2025, Int J Dent HygDOI PubMed Statement sourceLedger id ML2025 | RCT | water flosser | 78 adults 4 weeks | "The first author, Mancinelli-Lyle, was an employee of Water Pik, Inc. when the study was conducted. Van der Weijden is the owner of Jardin B.V., which is the former owner of www.ragershop.com (a webshop for various brands of interdental…"The first author, Mancinelli-Lyle, was an employee of Water Pik, Inc. when the study was conducted. Van der Weijden is the owner of Jardin B.V., which is the former owner of www.ragershop.com (a webshop for various brands of interdental brushes). The study was performed by the Department of Periodontology of ACTA with a commission from ACTA Dental Research B.V. In turn ACTA Research B.V. received financial support from Water Pik, Inc. Fort Collins, CO. USA, Water Pik, Inc. Fort Collins, CO. USA provided the study products. The research team at ACTA of Slot and van der Weijden has previously received either external advisor fees, lecturer fees or research grants from oral health care manufacturers. Those manufacturers included Colgate, Dentaid, GABA, Lactona, Oral-B, Philips, Procter & Gamble, Sara Lee, Sunstar, TePe, Unilever & Water Pik."Read on 2026-09-15 at the statement source | "The authors declare that there are no conflicts of interest." | RCT · water flosser · 78 adults / 4 weeks · manufacturer-employed authors · basis: funding statement | manufacturer-employed authors Water Pik, Inc.basis: funding statement | do-water-flossers-work |
| Salivary flow, tongue-coating burden, and morning breath odor: a cross-sectional studyPopa M, 2025, J Clin MedDOI PubMed Statement sourceLedger id POPA2025 | cross-sectional | bad breath | 92 young adults — | "The Article Processing Charge (APC) was covered by ‘Victor Babeș’ University of Medicine and Pharmacy Timișoara. No external funding was received for the conduct of this research."Read on 2026-09-16 at the statement source | "The authors declare no conflicts of interest." | cross-sectional · bad breath · 92 young adults · none declared · basis: funding statement | none declared none declared (the university paid the publication fee)basis: funding statement | bad-breath-causes |
| Opinion on hydroxyapatite (nano), submission IV, SCCS/1677/25Scientific Committee on Consumer Safety, 2025, European CommissionOfficial page Statement sourceLedger id SCCS2025 | guideline | hydroxyapatite | — — | Public body — not applicableRead on 2026-09-15 at the statement source | Public body — not applicable | guideline · hydroxyapatite · — · public/charity · basis: none available | public/charity European Commission (SCCS)basis: none available | is-hydroxyapatite-toothpaste-safe-to-swallownano-vs-micro-hydroxyapatite |
| Oral health benefits and safety of xylitol and potential cardiovascular risk: questioning the validity of the model of Witkowski et al.Valentine GC, 2025, Eur Heart JDOI PubMed Statement sourceLedger id EHJL1 | letter | xylitol | — — | "G.C.V. is supported by a grant from the National Institutes of Health (K23 HD105929)."Read on 2026-09-16 at the statement source | "All authors declare no disclosure of interest for this contribution." | letter · xylitol · — · public/charity · basis: funding statement | public/charity National Institutes of Health (one author’s grant)basis: funding statement | xylitol-for-teeth |
| Survey methods contributing to the difference of dentin hypersensitivity prevalence among publications between 1998 and 2022: a research-on-research studyWang G, 2025, BMC Oral HealthDOI PubMed Statement sourceLedger id DH2025 | meta-analysis | sensitivity | 39 prevalence studies — | "We would like to thank the support from Sichuan University and Luzhou government (2018 Sichuan University-Luzhou Municipal Government Strategic Cooperation Research (2018CDLZ-12))."Read on 2026-09-15 at the statement source | "The authors declare no competing interests." | meta-analysis · sensitivity · 39 prevalence studies · public/charity · basis: funding statement | public/charity Sichuan University and Luzhou governmentbasis: funding statement | sensitive-teeth-causes |
| Xylitol exposure and cardiovascular riskWölnerhanssen BK, 2025, Eur Heart JDOI PubMed Statement sourceLedger id EHJL2 | letter | xylitol | — — | No funding statement in the paperRead on 2026-09-16 at the statement source | "B.K.W. and A.C.M.-G.: nothing to declare. A.A.: founder and major shareholder of CoreQuest and Iperboreal Pharma." | letter · xylitol · — · not stated · basis: none available | not stated not statedbasis: none available | xylitol-for-teeth |
| Efficacy and safety of probiotic therapy for halitosis: a systematic review and meta-analysis of randomized controlled trialsYang Y, 2025, J Breath ResDOI PubMed Statement sourceLedger id PH2025 | meta-analysis | probiotics | 10 studies — | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled) | meta-analysis · probiotics · 10 studies · not stated · basis: none available | not stated not statedbasis: none available | do-oral-probiotics-work |
| Clinical efficacy of vestibular incision subperiosteal tunnel access (VISTA) for the treatment of gingival recession: a systematic review and meta-analysisZhu Q, 2025, BMC Oral HealthDOI PubMed Statement sourceLedger id VISTA2025 | meta-analysis | recession | 14 studies, 226 patients — | "Effect of non-impacted third molars on the periodontal health of adjacent teeth."Read on 2026-09-15 at the statement source | "The authors declare no competing interests." | meta-analysis · recession · 14 studies, 226 patients · not stated · basis: funding statement | not stated Named as a project title only — funder not statedbasis: funding statement | receding-gums-causes |
| Over-the-counter products in tooth bleaching: A scoping reviewBarbosa LMM, 2024, J DentDOI PubMed Statement sourceLedger id BARBOSA2024 | systematic review | whitening | 88 studies — | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Department of Restorative Dentistry, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil. | Nova Esperança School (Facene), João Pessoa, Paraíba, Brazil. | Dental Materials Division, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil. | Department of Dentistry, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil. | ATITUS Educação, Meridional Faculty, Passo Fundo, Rio Grande do Sul, Brazil. | Department of Restorative Dentistry, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil. Electronic address: renally.lima@academico.ufpb.br. (record) | systematic review · whitening · 88 studies · not stated · basis: none available | not stated not statedbasis: none available | do-whitening-strips-damage-enamel |
| The effectiveness of water jet flossing and interdental flossing for oral hygiene in orthodontic patients with fixed appliances: a randomized clinical trialAlMoharib HS, 2024, BMC Oral HealthDOI Statement sourceLedger id ALMO2024 | RCT | water flosser | — — | "This study was funded by the Saudi Society of Periodontology, Riyadh, Saudi Arabia."Read on 2026-09-16 at the statement source | "The authors declare no competing interests." | RCT · water flosser · — · public/charity · basis: funding statement | public/charity Saudi Society of Periodontologybasis: funding statement | not yet cited |
| Should we wait to brush our teeth? A scoping review regarding dental caries and erosive tooth wearFernández CE, 2024, Caries ResDOI PubMed Statement sourceLedger id FERN2024 | systematic review | erosion | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca, Talca, Chile. (record) | systematic review · erosion · — · not stated · basis: none available | not stated not statedbasis: none available | enamel-erosion-causes |
| The effect of oil pulling in comparison with chlorhexidine and other mouthwash interventions in promoting oral health: a systematic review and meta-analysisJong FJX, 2024, Int J Dent HygDOI PubMed Statement sourceLedger id OP2024 | meta-analysis | oil pulling | 25 trials, 1,184 participants 7 to 45 days | "The authors declare no funds or financial support."Read on 2026-09-15 at the statement source | "The authors declare no competing interests." | meta-analysis · oil pulling · 25 trials, 1,184 participants / 7 to 45 days · none declared · basis: funding statement | none declared none declaredbasis: funding statement | oil-pulling-does-it-work |
| Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-AnalysisMayta-Tovalino F, 2024, Int Dent JDOI PubMed Statement sourceLedger id PB2024 | meta-analysis | probiotics | 19 RCTs, 2,622 children and adolescents 0.2 months and longer | "This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors."Read on 2026-09-15 at the statement source | "The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper." | meta-analysis · probiotics · 19 RCTs, 2,622 children and adolescents / 0.2 months and longer · none declared · basis: funding statement | none declared none declaredbasis: funding statement | do-oral-probiotics-work |
| Clinical evidence of caries prevention by hydroxyapatite: an updated systematic review and meta-analysisPawinska M, 2024, J DentDOI PubMed Statement sourceLedger id PW2024 | meta-analysis | hydroxyapatite | 5 clinical and 8 in situ trials — | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled) | meta-analysis · hydroxyapatite · 5 clinical and 8 in situ trials · not stated · basis: none available | not stated not statedbasis: none available | do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpaste |
| The effect of xylitol chewing gums and candies on caries occurrence in children: a systematic review with special reference to caries level at study baselinePienihäkkinen K, 2024, Eur Arch Paediatr DentDOI PubMed Statement sourceLedger id EAPD2024 | systematic review | xylitol | 15 articles; ten gum studies — | "Open Access funding provided by University of Turku (including Turku University Central Hospital)."Read on 2026-09-16 at the statement source | "The authors report no conflict of interest." | systematic review · xylitol · 15 articles; ten gum studies · public/charity · basis: funding statement | public/charity University of Turku (open-access fee)basis: funding statement | xylitol-for-teeth |
| Do chewing gums and sweets containing xylitol prevent caries in children?Ramasubbu D, 2024, Evid Based DentDOI PubMed Statement sourceLedger id EBD2024 | commentary | xylitol | — — | "Open Access funding provided by the IReL Consortium."Read on 2026-09-16 at the statement source | "The authors declare no competing interests." | commentary · xylitol · — · public/charity · basis: funding statement | public/charity IReL Consortium (open-access fee)basis: funding statement | xylitol-for-teeth |
| Xylitol is prothrombotic and associated with cardiovascular riskWitkowski M, 2024, Eur Heart JDOI PubMed Statement sourceLedger id EHJ2024 | cohort | xylitol | 3,306 patients (discovery and validation cohorts); 10 healthy volunteers (xylitol ingestion) 3-year follow-up | "This work is supported by grants from the NIH and Office of Dietary Supplements (P01 HL147823, R01 HL103866), the Deutsche Forschungsgemeinschaft (WI 5229/1-1), and the Deutsche Stifterverband (S0199/10098/2023)."Read on 2026-09-16 at the statement source | "S.L.H. and Z.W. report being named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. S.L.H. and Z.W. also report having received royalty payments for…"S.L.H. and Z.W. report being named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. S.L.H. and Z.W. also report having received royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland Heart Lab, a fully owned subsidiary of Quest Diagnostics, and Procter & Gamble. S.L.H. is a paid consultant for Zehna Therapeutics and formerly for Proctor & Gamble; has received research funds from Zehna Therapeutics, Proctor & Gamble, Pfizer, and Roche Diagnostics; and is eligible to receive royalty payments for inventions or discoveries related to cardiovascular diagnostics and therapeutics from Zehna Therapeutics. W.H.W.T. reports being a consultant for Sequana Medical A.G., Owkin Inc., Relypsa Inc., and PreCardiac Inc. and having received honorarium from Springer Nature for authorship/editorship and American Board of Internal Medicine for exam writing committee participation—all unrelated to the subject and contents of this paper. The other authors have reported that they have no relationships relevant to the contents of this paper to disclose." | cohort · xylitol · 3,306 patients (discovery and validation cohorts); 10 healthy volunteers (xylitol ingestion) / 3-year follow-up · public/charity · basis: funding statement | public/charity NIH and Office of Dietary Supplements; Deutsche Forschungsgemeinschaft; Deutsche Stifterverbandbasis: funding statement | xylitol-for-teeth |
| The effectiveness of oral irrigators on periodontal health status and oral hygiene of orthodontic patients: a systematic review and meta-analysisZarei Z, 2024, BMC Oral HealthDOI Statement sourceLedger id ZAREI2024 | meta-analysis | water flosser | 7 trials — | "Have no financial or non- financial support."Read on 2026-09-16 at the statement source | "The authors declare no competing interests." | meta-analysis · water flosser · 7 trials · none declared · basis: funding statement | none declared none declaredbasis: funding statement | not yet cited |
| Tongue-coating microbial and metabolic characteristics in halitosisZhang Y, 2024, J Dent ResDOI PubMed Statement sourceLedger id JDR2024 | cross-sectional | bad breath | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Department of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (record) | cross-sectional · bad breath · — · not stated · basis: none available | not stated not statedbasis: none available | bad-breath-causes |
| In Vitro Evaluation of Tooth-Whitening Potential of Peroxide-Free OTC Dental Bleaching AgentsGrillon M, 2023, Dent J (Basel)DOI PubMed Statement sourceLedger id GRILLON2023 | laboratory | whitening | 80 bovine incisors up to 200 minutes of product exposure | Funding: "No grant was received for this study; the products were purchased and paid for by our division (Division of Cariology and Endodontology, Section of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland)."Read on 2026-09-23 at the statement source | Conflicts of Interest: "The authors declare no conflict of interest." | laboratory · whitening · 80 bovine incisors / up to 200 minutes of product exposure · public/charity · basis: funding statement | public/charity University of Geneva (the authors’ own division)basis: funding statement | do-whitening-strips-damage-enamel |
| Clinical evidence of biomimetic hydroxyapatite in oral care products for reducing dentin hypersensitivity: an updated systematic review and meta-analysisLimeback H, 2023, Biomimetics (Basel)DOI PubMed Statement sourceLedger id LIME2023 | meta-analysis | hydroxyapatite | — — | "This research received no external funding."Read on 2026-09-16 at the statement source | "J.E. and F.M. are senior scientists and employees of Dr. Kurt Wolff GmbH & Co. KG in Germany." | meta-analysis · hydroxyapatite · — · manufacturer-employed authors · basis: competing-interests statement | manufacturer-employed authors Dr. Kurt Wolff GmbH & Co. KGbasis: competing-interests statement | do-dentists-recommend-hydroxyapatitesensitive-teeth-toothpaste |
| Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trialPaszynska E, 2023, Front Public HealthDOI PubMed Statement sourceLedger id P2023 | non-inferiority RCT | hydroxyapatite | 189 adults 18 months | "This research was funded by Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany, and both universities, the Poznan University of Medical Sciences in Poznan and the Medical University in Bialystok, Poland."Read on 2026-09-15 at the statement source | "JE, FM, and ESc are employees of Dr. Kurt Wolff GmbH and Co. KG, Bielefeld, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a…"JE, FM, and ESc are employees of Dr. Kurt Wolff GmbH and Co. KG, Bielefeld, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest." | non-inferiority RCT · hydroxyapatite · 189 adults / 18 months · manufacturer · basis: funding statement | manufacturer Dr. Kurt Wolff GmbH & Co. KG, with two universitiesbasis: funding statement | do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpastenano-vs-micro-hydroxyapatite |
| Formulations of desensitizing toothpastes for dentin hypersensitivity: a scoping reviewMartins CC, 2022, J Appl Oral SciDOI PubMed Statement sourceLedger id MARTINS2022 | systematic review | sensitivity | 138 RCTs — | Funding: "CCM received a postdoctoral fellowship from CAPES (Coordination for the Improvement of Higher Educational Personnel, Ministry of Education, Brazil, process #88881.119166/2016-01), during her post-doctoral studies at McMaster…Funding: "CCM received a postdoctoral fellowship from CAPES (Coordination for the Improvement of Higher Educational Personnel, Ministry of Education, Brazil, process #88881.119166/2016-01), during her post-doctoral studies at McMaster University. RTF was supported by CAPES. JJR was supported by a PhD training award from the NCMIC Foundation."Read on 2026-09-23 at the statement source | Conflict of interest: "The authors declare no potential conflicts of interest regarding the authorship and/or publication of this article." | systematic review · sensitivity · 138 RCTs · public/charity · basis: funding statement | public/charity CAPES (Brazilian Ministry of Education); NCMIC Foundationbasis: funding statement | sensitive-teeth-toothpaste |
| Health Products Compliance GuidanceFederal Trade Commission, 2022, FTCOfficial page Statement sourceLedger id FTC2022 | guideline | health claims | — — | Public body — not applicableRead on 2026-09-15 at the statement source | Public body — not applicable | guideline · health claims · — · public/charity · basis: none available | public/charity Federal Trade Commissionbasis: none available | reference-checker |
| Effectiveness of oil pulling for improving oral health: a meta-analysisPeng TR, 2022, Healthcare (Basel)DOI PubMed Statement sourceLedger id OP2022 | meta-analysis | oil pulling | 9 RCTs — | Funding: "This research received no external funding." Acknowledgments: "This study was supported by grants from the Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-TPE-111-54)."Read on 2026-09-15 at the statement source | "The authors declare no conflict of interest." | meta-analysis · oil pulling · 9 RCTs · public/charity · basis: funding statement | public/charity Taipei Tzu Chi Hospital (per the acknowledgements)basis: funding statement | oil-pulling-does-it-work |
| The effect of mechanical tongue cleaning on oral malodor and tongue coatingChoi HN, 2021, Int J Environ Res Public HealthDOI PubMed Statement sourceLedger id CHOI2021 | RCT | tongue scraping | three groups: toothbrush, scraper, both single session | "This research received no external funding."Read on 2026-09-16 at the statement source | "The authors declare no conflict of interest." | RCT · tongue scraping · three groups: toothbrush, scraper, both / single session · none declared · basis: funding statement | none declared none declaredbasis: funding statement | tongue-scraping |
| Efficacy of a zinc lactate mouthwash and tongue scraping in the reduction of intra-oral halitosis: a single-blind, controlled, crossover clinical trial — a pilot studyDudzik A, 2021, J Clin MedDOI PubMed Statement sourceLedger id DUD2021 | RCT | tongue scraping | 60 volunteers two 14-day protocols | "This research received no external funding."Read on 2026-09-16 at the statement source | "The authors declare no conflict of interest." | RCT · tongue scraping · 60 volunteers / two 14-day protocols · none declared · basis: funding statement | none declared none declaredbasis: funding statement | tongue-scraping |
| Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysisLimeback H, 2021, Can J Dent HygPubMed Statement sourceLedger id LIME2021 | meta-analysis | hydroxyapatite | — — | No funding statement in the paperRead on 2026-09-16 at the statement source | No statement in the paperAffiliations on PubMed: Senior scientist, Oral care, Dr. Kurt Wolff GmbH & Co. KG, Research Department, Bielefeld, Germany (Enax J; Meyer F) (record) | meta-analysis · hydroxyapatite · — · manufacturer-employed authors · basis: affiliation (PubMed) | manufacturer-employed authors Dr. Kurt Wolff GmbH & Co. KGbasis: affiliation (PubMed) | do-dentists-recommend-hydroxyapatite |
| Delivering better oral health: an evidence-based toolkit for preventionOffice for Health Improvement and Disparities, 2021, gov.ukOfficial page Statement sourceLedger id DBOH | guideline | fluoride | — — | Public body — not applicableRead on 2026-09-15 at the statement source | Public body — not applicable | guideline · fluoride · — · public/charity · basis: none available | public/charity Office for Health Improvement and Disparities (UK government)basis: none available | do-whitening-strips-damage-enamelhydroxyapatite-vs-fluoride-for-kidsis-hydroxyapatite-toothpaste-safe-to-swallowsensitive-teeth-causessensitive-teeth-toothpastetoothpaste-ingredient-decoder |
| Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trialPaszynska E, 2021, Sci RepDOI PubMed Statement sourceLedger id P2021 | non-inferiority RCT | hydroxyapatite | 207 children 336 days | "This study was funded by Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany. The funders had no role in recruiting, conduction of the study, data collection, and statistical analysis."Read on 2026-09-15 at the statement source | "The authors declare no competing interest." | non-inferiority RCT · hydroxyapatite · 207 children / 336 days · manufacturer · basis: funding statement | manufacturer Dr. Kurt Wolff GmbH & Co. KGbasis: funding statement | do-dentists-recommend-hydroxyapatitehydroxyapatite-vs-fluoride-for-kidsnano-vs-micro-hydroxyapatite |
| Changes in tonsillolith characteristics detected in a follow-up CT studyYamashita K, 2021, BMC Oral HealthDOI PubMed Statement sourceLedger id TS2021 | cohort | tonsil stones | 326 CT scan pairs follow-up CT examinations | "This study received no funding with respect to study design; the collection, analysis and interpretation of subject's data; or writing the manuscript."Read on 2026-09-15 at the statement source | "The authors declare that they have no competing interests." | cohort · tonsil stones · 326 CT scan pairs / follow-up CT examinations · none declared · basis: funding statement | none declared none declaredbasis: funding statement | bad-breath-causes |
| Desensitizing Toothpastes for Dentin Hypersensitivity: A Network Meta-analysisMartins CC, 2020, J Dent ResDOI PubMed Statement sourceLedger id MARTINS2020 | meta-analysis | sensitivity | 125 RCTs, 12,541 patients — | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Pediatric Dentistry and Orthodontics, Federal University of Minas Gerais, Belo Horizonte, Brazil. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Pediatric Dentistry and Orthodontics, Federal University of Minas Gerais, Belo Horizonte, Brazil. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Family Medicine; McMaster University, Hamilton, ON, Canada. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, China. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Oral and Craniofacial Health Science, School of Dentistry, University of North Carolina at Chapel Hill, NC, USA. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Dentistry, State University of Paraíba, Campina Grande, Brazil. | Department of Clinical, Pathology and Oral Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | School of Medicine, Universidad de los Andes, Bogotá, Colombia. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. (record) | meta-analysis · sensitivity · 125 RCTs, 12,541 patients · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
| Mouthwash with alcohol and oral carcinogenesis: systematic review and meta-analysisAceves Argemí R, 2020, J Evid Based Dent PractDOI PubMed Statement sourceLedger id ACEVES2020 | meta-analysis | mouthwash | 14 articles (11 case-control, 3 clinical) — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled) | meta-analysis · mouthwash · 14 articles (11 case-control, 3 clinical) · not stated · basis: none available | not stated not statedbasis: none available | is-mouthwash-bad-for-you |
| Risk-based, 6-monthly and 24-monthly dental check-ups for adults: the INTERVAL three-arm RCTClarkson JE, 2020, Health Technol AssessDOI PubMed Statement sourceLedger id C2020 | RCT | recall interval | 2,372 adults 4 years | "This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme [project numbers 06/35/05 (Phase I) and 06/35/99 (Phase II)] and will be published in full in Health Technology…"This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme [project numbers 06/35/05 (Phase I) and 06/35/99 (Phase II)] and will be published in full in Health Technology Assessment; Vol. 24, No. 60. See the NIHR Journals Library website for further project information."Read on 2026-09-15 at the statement source | "Nigel B Pitts consults for Colgate (Colgate-Palmolive Company, New York, NY, USA) and GlaxoSmithKline plc (Brentford, UK) (toothpaste manufacturers) and was also a co-applicant on the National Institute for Health Research (NIHR) Health…"Nigel B Pitts consults for Colgate (Colgate-Palmolive Company, New York, NY, USA) and GlaxoSmithKline plc (Brentford, UK) (toothpaste manufacturers) and was also a co-applicant on the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Improving the Quality of Dentistry trial of dental scale and polish. Craig R Ramsay is a member of the NIHR HTA General Board. John DT Norrie reports grants from the University of Aberdeen and grants from the University of Edinburgh during the conduct of the study, and declares membership of the following NIHR boards: CPR decision making committee, HTA Commissioning Board, HTA Commissioning Sub-Board (Expression of Interest), HTA Funding Boards Policy Group, HTA General Board, HTA Post-Board funding teleconference, NIHR Clinical Trials Unit Standing Advisory Committee, NIHR HTA and Efficacy and Mechanism Evaluation Editorial Board and the Pre-exposure Prophylaxis Impact Review Panel. Gail Douglas reports that she is employed full time by the University of Leeds; 1 day of her time is bought out by Public Health England to assist with academic input to the dental epidemiology programme for England. She is also currently President of the British Association for the Study of Community Dentistry, a professional organisation principally for those working in the field of dental public health or allied areas." | RCT · recall interval · 2,372 adults / 4 years · public/charity · basis: funding statement | public/charity NIHR Health Technology Assessment programmebasis: funding statement | what-a-dental-cleaning-does |
| Recall intervals for oral health in primary care patientsFee PA, 2020, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id F2020 | systematic review | recall interval | 2 trials, 1,736 participants 2 to 4 years | "Internal sources: School of Dentistry, The University of Manchester, UK. Scottish Executive, UK. University College Cork, Ireland. MAHSC, UK. Cochrane Oral Health is supported by the Manchester Academic Health Sciences Centre (MAHSC) and…"Internal sources: School of Dentistry, The University of Manchester, UK. Scottish Executive, UK. University College Cork, Ireland. MAHSC, UK. Cochrane Oral Health is supported by the Manchester Academic Health Sciences Centre (MAHSC) and the NIHR Manchester Biomedical Research Centre. External sources: Cochrane Fellowship - Health Research Board, Ireland. Department of Health Cochrane Review Incentive Scheme, UK. National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the Evidence Synthesis Programme, the NIHR, NHS, or the Department of Health and Social Care. Cochrane Oral Health Group Global Alliance, UK. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors in the last two years have been the American Association of Public Health Dentistry, USA; AS-Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Swiss Society of Endodontology, Switzerland."Read on 2026-09-15 at the statement source | "PF: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. PR: no interests to declare. HW: was involved with one of…"PF: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. PR: no interests to declare. HW: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. Professor Worthington is a Co-ordinating Editor with Cochrane Oral Health. JC: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. Professor Clarkson is a Co-ordinating Editor with Cochrane Oral Health. DB: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. PB: no interests to declare." | systematic review · recall interval · 2 trials, 1,736 participants / 2 to 4 years · public/charity · basis: funding statement | public/charity NIHR, via Cochrane Infrastructure funding to Cochrane Oral Healthbasis: funding statement | what-a-dental-cleaning-does |
| Does delayed toothbrushing after the consumption of erosive foodstuffs or beverages decrease erosive tooth wear? A systematic review and meta-analysisHong DW, 2020, Clin Oral InvestigDOI PubMed Statement sourceLedger id DT2020 | meta-analysis | erosion | 12 in situ and in vitro studies — | "This study was partially supported by the Guiding Project for Science and Technology of Fujian Province (2018Y0029), and the Joint Fund for Scientific and Technological Innovation of Fujian Province (2019Y9030)."Read on 2026-09-15 at the statement source | "The authors declare that they have no conflict of interest." | meta-analysis · erosion · 12 in situ and in vitro studies · public/charity · basis: funding statement | public/charity Fujian Province science and technology fundsbasis: funding statement | enamel-erosion-causes |
| Dental checks: intervals between oral health reviews (CG19) and 2020 surveillance decisionNICE, 2020, NICEOfficial page Statement sourceLedger id NICE19 | guideline | recall interval | — — | Public body — not applicableRead on 2026-09-15 at the statement source | Public body — not applicable | guideline · recall interval · — · public/charity · basis: none available | public/charity NICEbasis: none available | what-a-dental-cleaning-does |
| The effect of oil pulling with coconut oil to improve dental hygiene and oral health: a systematic reviewWoolley J, 2020, HeliyonDOI PubMed Statement sourceLedger id OP2020 | systematic review | oil pulling | 4 trials, 182 participants 7 to 30 days | "This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors."Read on 2026-09-16 at the statement source | "The authors declare no conflict of interest." | systematic review · oil pulling · 4 trials, 182 participants / 7 to 30 days · none declared · basis: funding statement | none declared none declaredbasis: funding statement | oil-pulling-does-it-work |
| Network meta-analysis on the effect of desensitizing toothpastes on dentine hypersensitivityHu ML, 2019, J DentDOI PubMed Statement sourceLedger id HU2019 | meta-analysis | sensitivity | 30 RCTs 2, 4 and 8 weeks | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. Electronic address: dentalhan@126.com. (record) | meta-analysis · sensitivity · 30 RCTs / 2, 4 and 8 weeks · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpastesensitive-teeth-causes |
| Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysisde Melo Alencar C, 2019, J DentDOI PubMed Statement sourceLedger id ALENCAR2019 | meta-analysis | sensitivity | 6 RCTs 4 weeks | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: School of Dentistry, Federal University of Para, Belém, PA, Brazil. | School of Dentistry, Federal University of Para, Belém, PA, Brazil. | School of Dentistry, Federal University of Para, Belém, PA, Brazil. | School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. | School of Dentistry, Federal University of Para, Belém, PA, Brazil. Electronic address: cecymsilva@gmail.com. | School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. (record) | meta-analysis · sensitivity · 6 RCTs / 4 weeks · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
| Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeksHirsiger C, 2019, J DentDOI PubMed Statement sourceLedger id HIRSIGER2019 | RCT | sensitivity | 297 randomised, 273 completed 24 weeks | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: constanze.hirsiger@zzm.uzh.ch. | Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: patrick.schmidlin@zzm.uzh.ch. | Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address: mary.michaelis@uk-halle.de. | Department of Pediatric Dentistry, University School of Dentistry, Liebigstraße 10 - 14, 04103, Leipzig, Germany. Electronic address: kizhk@medizin.uni-leipzig.de. | Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: thomas.attin@zzm.uzh.ch. | Department of Statistics, Ludwig-Maximilian-University, Ludwigstrasse 33, 80539, Munich, Germany. Electronic address: christian.heumann@stat.uni-muenchen.de. | Univ Clermont Auvergne, UFR d'Odontologie; Centre de Recherche en Odontologie Clinique EA 4847, Rue de Braga 2, F-63000 Clermont-Ferrand; CHU Estaing Clermont-Ferrand, Service d'Odontologie, Hôtel-, F-63001, Clermont-Ferrand, France. Electronic address: sophie.domejean@uca.fr. | Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address: christian.gernhardt@uk-halle.de. (record) | RCT · sensitivity · 297 randomised, 273 completed / 24 weeks · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
| Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in childrenAmaechi BT, 2019, BDJ OpenDOI PubMed Statement sourceLedger id A2019 | in situ | hydroxyapatite | 30 adults 14 days per arm | No funding statement in the paperRead on 2026-09-15 at the statement source | "The authors declare no competing interests." | in situ · hydroxyapatite · 30 adults / 14 days per arm · not stated · basis: competing-interests statement | not stated not statedbasis: competing-interests statement | do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpaste |
| Home use of interdental cleaning devices and toothbrushing and their role in disease preventionGallie A, 2019, Evid Based DentDOI PubMed Statement sourceLedger id EBD2019 | commentary | flossing | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: King’s College London, London, UK. (record) | commentary · flossing · — · not stated · basis: none available | not stated not statedbasis: none available | what-the-flossing-evidence-actually-measured |
| Occurrence and predictors of gingivitis and supragingival calculus in a population of Brazilian adultsHaas AN, 2019, Braz Oral ResDOI PubMed Statement sourceLedger id PA2019 | cross-sectional | calculus | 758 adults aged 35 to 59 — | No funding statement in the paperRead on 2026-09-15 at the statement source | "The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript." | cross-sectional · calculus · 758 adults aged 35 to 59 · not stated · basis: competing-interests statement | not stated not statedbasis: competing-interests statement | 48-hoursplaque-vs-tartar |
| Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: a randomized, controlled 6-month trialSchlagenhauf U, 2019, J Investig Clin DentDOI PubMed Statement sourceLedger id S2019 | RCT | hydroxyapatite | 147 orthodontic patients 6 months | "The study was exclusively funded by Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany"Read on 2026-09-15 at the statement source | No statement in the paper | RCT · hydroxyapatite · 147 orthodontic patients / 6 months · manufacturer · basis: funding statement | manufacturer Dr. Kurt Wolff GmbH & Co. KGbasis: funding statement | do-dentists-recommend-hydroxyapatitenano-vs-micro-hydroxyapatite |
| Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental cariesWorthington HV, 2019, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id W2019 | systematic review | flossing | 35 trials, 3,929 adults 4 weeks to 6 months | "Internal sources: School of Dentistry, The University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), the NIHR Manchester Biomedical Research Centre, UK. External sources: National Institute for Health Research (NIHR),…"Internal sources: School of Dentistry, The University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), the NIHR Manchester Biomedical Research Centre, UK. External sources: National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health. Cochrane Oral Health Global Alliance, Other. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors over the past year have been the American Association of Public Health Dentistry, USA; AS-Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and the Swiss Society for Endodontology, Switzerland."Read on 2026-09-15 at the statement source | "Helen Worthington: none known. Co-ordinating Editor of Cochrane Oral Health. Author on one included study (assessed by other review authors). Laura MacDonald: none known. Managing Editor with Cochrane Oral Health. Tina Poklepovic Pericic:…"Helen Worthington: none known. Co-ordinating Editor of Cochrane Oral Health. Author on one included study (assessed by other review authors). Laura MacDonald: none known. Managing Editor with Cochrane Oral Health. Tina Poklepovic Pericic: none known. Dario Sambunjak: none known. Trevor Johnson: none known. Editor with Cochrane Oral Health. Pauline Imai: none known. Author on one included study (assessed by other review authors). Jan Clarkson: none known. Co-ordinating Editor of Cochrane Oral Health." | systematic review · flossing · 35 trials, 3,929 adults / 4 weeks to 6 months · public/charity · basis: funding statement | public/charity NIHR, via Cochrane Infrastructure funding to Cochrane Oral Healthbasis: funding statement | do-water-flossers-workhow-often-should-you-flosswhat-the-flossing-evidence-actually-measured |
| Sugar restriction for caries prevention: amount and frequency. Which is more important?van Loveren C, 2019, Caries ResDOI PubMed Statement sourceLedger id VL2019 | narrative review | sugar | — — | No funding statement in the paperRead on 2026-09-15 at the statement source | "The author declares no conflicts of interest." | narrative review · sugar · — · not stated · basis: competing-interests statement | not stated not statedbasis: competing-interests statement | can-teeth-remineralise |
| Home-based chemically-induced whitening (bleaching) of teeth in adultsEachempati P, 2018, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id EACH2018 | systematic review | whitening | 71 trials; 26 against placebo (1,398 participants) 2 weeks to 6 months | Internal sources: "Faculty of Dentistry, Melaka‐Manipal Medical College, Manipal University, Melaka Campus, Malaysia." External sources: "National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via…Internal sources: "Faculty of Dentistry, Melaka‐Manipal Medical College, Manipal University, Melaka Campus, Malaysia." External sources: "National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health. Cochrane Oral Health Global Alliance, Other. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships‐alliances). Contributors over the past year have been the American Association of Public Health Dentistry, USA; AS‐Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; NHS Education for Scotland, UK; and the Swiss Society for Endodontology, Switzerland."Read on 2026-09-23 at the statement source | Declarations of interest: "Prashanti Eachempati: none known. Sumanth Kumbargere Nagraj: none known. Salian Kiran Kumar Krishanappa: none known. Puneet Gupta: none known. Ibrahim Ethem Yaylali: none known." | systematic review · whitening · 71 trials; 26 against placebo (1,398 participants) / 2 weeks to 6 months · public/charity · basis: funding statement | public/charity NIHR (UK), via Cochrane infrastructure funding; Cochrane Oral Health Global Alliancebasis: funding statement | do-whitening-strips-damage-enamel |
| Effect of desensitizing toothpastes on dentine hypersensitivity: A systematic review and meta-analysisHu ML, 2018, J DentDOI PubMed Statement sourceLedger id HU2018 | meta-analysis | sensitivity | 53 RCTs, 4,796 patients — | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. Electronic address: linhong611@163.com. (record) | meta-analysis · sensitivity · 53 RCTs, 4,796 patients · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
| Evaluation of the addition of a water flosser to manual brushing on gingival healthGoyal CR, 2018, J Clin DentPubMed Statement sourceLedger id G2018 | RCT | water flosser | 72 adults 4 weeks | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: All Sum Research Center, Mississauga, Ontario, Canada. | All Sum Research Center, Mississauga, Ontario, Canada. | Reinhard Schuller Consulting, Toronto, Ontario, Canada. | Water Pik, Inc., Fort Collins, CO., USA. (record) | RCT · water flosser · 72 adults / 4 weeks · manufacturer-employed authors · basis: affiliation (PubMed) | manufacturer-employed authors Water Pik, Inc.basis: affiliation (PubMed) | do-water-flossers-work |
| Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trialInvernici MM, 2018, J Clin PeriodontolDOI PubMed Statement sourceLedger id I2018 | RCT | probiotics | 41 patients 90 days | "The study was supported by the National Council for Scientific and Technological Development (CNPq - process #480982/2013-9) awarded to Michel R. Messora. DuPont de Nemours & Co. Danisco Sweeteners Oy (Kantvik, Finland) donated the probiotics."Read on 2026-09-15 at the statement source | "The authors have stated explicitly that there are no conflict of interests in connection with this article." | RCT · probiotics · 41 patients / 90 days · mixed · basis: funding statement | mixed CNPq (grant); DuPont Danisco (donated the probiotics)basis: funding statement | checking-supplement-sciencedo-oral-probiotics-work |
| In silico modelling to differentiate the contribution of sugar frequency versus total amount in driving biofilm dysbiosis in dental cariesHead D, 2017, Sci RepDOI PubMed Statement sourceLedger id HEAD2017 | laboratory | sugar | — (computational model) — | Acknowledgements: "This work was funded by the School of Computing, University of Leeds, United Kingdom and the School of Dentistry, University of Leeds, United Kingdom. The views expressed are those of the authors and not necessarily…Acknowledgements: "This work was funded by the School of Computing, University of Leeds, United Kingdom and the School of Dentistry, University of Leeds, United Kingdom. The views expressed are those of the authors and not necessarily those of the funding bodies."Read on 2026-09-16 at the statement source | "The authors declare that they have no competing interests." | laboratory · sugar · — (computational model) · public/charity · basis: funding statement | public/charity University of Leeds (School of Computing and School of Dentistry)basis: funding statement | can-teeth-remineralise |
| Chlorhexidine mouthrinse as an adjunctive treatment for gingival healthJames P, 2017, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id J2017 | systematic review | mouthwash | 51 studies, 5,345 participants 4 weeks to 6 months | "Internal sources: Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, UK. External sources: Health Research Board Cochrane…"Internal sources: Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, UK. External sources: Health Research Board Cochrane Fellowship Scheme, Ireland. National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health. Cochrane Oral Health Global Alliance, Other. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors over the past year have been the American Association of Public Health Dentistry, USA; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and NHS Education for Scotland, UK."Read on 2026-09-15 at the statement source | "As former Director of the Oral Health Services Research Centre, Cork, Helen Whelton has conducted clinical trials of products for GlaxoSmithKline (GSK) and she received consultancy fees in relation to this research. Mairead Harding…"As former Director of the Oral Health Services Research Centre, Cork, Helen Whelton has conducted clinical trials of products for GlaxoSmithKline (GSK) and she received consultancy fees in relation to this research. Mairead Harding (Deputy Director of the Oral Health Services Research Centre) was involved in the development of educational materials with regard to tooth wear/dental erosion and has conducted epidemiological studies and presented the findings on tooth wear and dental erosion at conferences. Fees received from GlaxoSmithKline for this work were paid to the Oral Health Services Research Centre, Cork and not to Mairead Harding. Philip Riley is a salaried member of the Cochrane Oral Health editorial team. Editorial control of the review and final decisions about the content of the review were maintained by Helen Worthington who is Co-ordinating Editor of Cochrane Oral Health. The remaining co-authors declare no conflict of interest." | systematic review · mouthwash · 51 studies, 5,345 participants / 4 weeks to 6 months · public/charity · basis: funding statement | public/charity NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health; Health Research Board, Irelandbasis: funding statement | is-mouthwash-bad-for-you |
| Timing of dietary acid intake and erosive tooth wear: a case-control studyO’Toole S, 2017, J DentDOI PubMed Statement sourceLedger id OTOOLE2017 | case-control | erosion | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled) | case-control · erosion · — · not stated · basis: none available | not stated not statedbasis: none available | enamel-erosion-causes |
| Effect of oil pulling in promoting oro dental hygiene: a systematic review of randomized clinical trialsGbinigie O, 2016, Complement Ther MedDOI PubMed Statement sourceLedger id OP2016 | systematic review | oil pulling | 5 trials, 160 participants — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: University of Oxford, Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, New Radcliffe House, Radcliffe Observatory Quarter, Oxford OX2 6GG, United Kingdom. (record) | systematic review · oil pulling · 5 trials, 160 participants · not stated · basis: none available | not stated not statedbasis: none available | oil-pulling-does-it-work |
| Evaluation of the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment—A systematic review and meta-analysisWang Y, 2015, J DentDOI PubMed Statement sourceLedger id WANG2015 | meta-analysis | whitening | RCTs (number not given in the abstract) — | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan 430079, China. | The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan 430079, China. Electronic address: dryizhou@whu.edu.cn. | Indiana University School of Dentistry, Indianapolis, IN, USA. (record) | meta-analysis · whitening · RCTs (number not given in the abstract) · not stated · basis: none available | not stated not statedbasis: none available | do-whitening-strips-damage-enamel |
| Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysisBae JH, 2015, J Clin PeriodontolDOI PubMed Statement sourceLedger id BAE2015 | meta-analysis | sensitivity | 31 RCTs — | Conflict of interest and source of funding statement: "The authors declare that there are no conflicts of interest in this study. No external funding was available for this study."Read on 2026-09-23 at the statement source | Conflict of interest and source of funding statement: "The authors declare that there are no conflicts of interest in this study. No external funding was available for this study." | meta-analysis · sensitivity · 31 RCTs · none declared · basis: funding statement | none declared none declaredbasis: funding statement | sensitive-teeth-toothpaste |
| Xylitol-containing products for preventing dental caries in children and adultsRiley P, 2015, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id R2015 | systematic review | xylitol | 10 studies, 5,903 participants varied; the toothpaste trials ran about 3 years | "Internal sources: The University of Manchester, UK. Manchester Academic Health Sciences Centre (MAHSC), UK. The Cochrane Oral Health Group is supported by MAHSC and the NIHR Manchester Biomedical Research Centre. External sources:…"Internal sources: The University of Manchester, UK. Manchester Academic Health Sciences Centre (MAHSC), UK. The Cochrane Oral Health Group is supported by MAHSC and the NIHR Manchester Biomedical Research Centre. External sources: National Institute for Health Research (NIHR), UK. The NIHR is the largest single funder of the Cochrane Oral Health Group. Disclaimer: The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR, NHS or the Department of Health. Cochrane Oral Health Group Global Alliance, Other. The production of all our reviews is assisted by funding from our Global Alliance partners (http://ohg.cochrane.org/): British Association for the Study of Community Dentistry, UK; British Association of Oral Surgeons, UK; British Orthodontic Society, UK; British Society of Paediatric Dentistry, UK; British Society of Periodontology, UK; Canadian Dental Hygienists Association, Canada; Mayo Clinic, USA; National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Royal College of Surgeons of Edinburgh, UK."Read on 2026-09-15 at the statement source | "There are no financial conflicts of interest and the review authors declare that they do not have any associations with any parties who may have vested interests in the results of this review." | systematic review · xylitol · 10 studies, 5,903 participants / varied; the toothpaste trials ran about 3 years · public/charity · basis: funding statement | public/charity NIHR and the Cochrane Oral Health Group Global Alliancebasis: funding statement | can-teeth-remineralisexylitol-for-teeth |
| Powered versus manual toothbrushing for oral healthYaacob M, 2014, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id Y2014 | systematic review | electric toothbrush | 56 trials, 5,068 participants 1 to 3 months and longer | "Internal sources: School of Dentistry, The University of Manchester, UK. School of Dentistry, The University of Birmingham, UK. Edinburgh Dental Institute, UK. University of Sheffield, School of Dentistry, UK. MAHSC, UK. The Cochrane Oral…"Internal sources: School of Dentistry, The University of Manchester, UK. School of Dentistry, The University of Birmingham, UK. Edinburgh Dental Institute, UK. University of Sheffield, School of Dentistry, UK. MAHSC, UK. The Cochrane Oral Health Group is supported by the Manchester Academic Health Sciences Centre (MAHSC) and the NIHR Manchester Biomedical Research Centre. External sources: Cochrane Oral Health Group Global Alliance, UK. All reviews in the Cochrane Oral Health Group are supported by Global Alliance member organisations (British Association of Oral Surgeons, UK; British Orthodontic Society, UK; British Society of Paediatric Dentistry, UK; British Society of Periodontology, UK; Canadian Dental Hygienists Association, Canada; Mayo Clinic, USA; National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Royal College of Surgeons of Edinburgh, UK) providing funding for the editorial process (http://ohg.cochrane.org/). National Institute for Health Research (NIHR), UK. CRG funding acknowledgement: The NIHR is the largest single funder of the Cochrane Oral Health Group. Disclaimer: The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR, NHS or the Department of Health."Read on 2026-09-15 at the statement source | "Bill Shaw and Helen Worthington were co-researchers on a randomised controlled trial sponsored by Braun AG (Clerehugh 1998) through a grant to The University of Manchester. Damien Walmsley was a consultant and undertook laboratory trials…"Bill Shaw and Helen Worthington were co-researchers on a randomised controlled trial sponsored by Braun AG (Clerehugh 1998) through a grant to The University of Manchester. Damien Walmsley was a consultant and undertook laboratory trials of powered toothbrushes sponsored by Braun AG through a grant to the University of Birmingham." | systematic review · electric toothbrush · 56 trials, 5,068 participants / 1 to 3 months and longer · public/charity · basis: funding statement | public/charity NIHR and the Cochrane Oral Health Group Global Alliancebasis: funding statement | electric-vs-manual-toothbrush |
| Effectiveness of arginine-containing toothpastes in treating dentine hypersensitivity: a systematic reviewSharif MO, 2013, J DentDOI PubMed Statement sourceLedger id SHARIF2013 | systematic review | sensitivity | — — | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: School of Dentistry, University of Manchester, Manchester, United Kingdom. mohammad.sharif@manchester.ac.uk (record) | systematic review · sensitivity · — · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
| Instant dentin hypersensitivity relief of a single topical application of an in-office desensitizing paste containing 8% arginine and calcium carbonate: a split-mouth, randomized-controlled studyKapferer I, 2013, Acta Odontol ScandDOI PubMed Statement sourceLedger id KAPFERER2013 | RCT | sensitivity | 30 subjects, 60 teeth 12 weeks | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Declaration of interest: "The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper."Affiliations on PubMed: Department of Restorative and Operative Dentistry, Dental School, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. ines.kapferer@gmx.net (record) | RCT · sensitivity · 30 subjects, 60 teeth / 12 weeks · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
| Evaluation of the plaque removal efficacy of a water flosser compared to string floss in adults after a single useGoyal CR, 2013, J Clin DentPubMed Statement sourceLedger id G2013 | RCT | water flosser | 70 adults single use | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: BioSci Research Canada Ltd., Mississauga, Ontario, Canada. (record) | RCT · water flosser · 70 adults / single use · not stated · basis: none available | not stated not statedbasis: none available | do-water-flossers-work |
| Physiological role for nitrate-reducing oral bacteria in blood pressure controlKapil V, 2013, Free Radic Biol MedDOI PubMed Statement sourceLedger id KAPIL2013 | cohort | mouthwash | 19 healthy volunteers 7-day control period, 7-day mouthwash period | Acknowledgments: "This work forms part of the research themes contributing to the translational research portfolio of the National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts and the London School of…Acknowledgments: "This work forms part of the research themes contributing to the translational research portfolio of the National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts and the London School of Medicine and Dentistry. V.K., V.P., and this work are supported by the British Heart Foundation. J.O.L. and E.W. have received grants from the Swedish Heart–Lung Foundation, Torsten and Ragnar Söderberg Foundation, Vinnova (CIDaT), and EU’s 6th Framework Program (Flaviola). A.A., J.O.L., and E.W. are all directors of Heartbeet Ltd."Read on 2026-09-16 at the statement source | No statement in the paper | cohort · mouthwash · 19 healthy volunteers / 7-day control period, 7-day mouthwash period · public/charity · basis: funding statement | public/charity British Heart Foundation; NIHR Cardiovascular Biomedical Research Unit (per the acknowledgments)basis: funding statement | is-mouthwash-bad-for-you |
| Brushing force of manual and sonic toothbrushes affects dental hard tissue abrasionWiegand A, 2013, Clin Oral InvestigDOI PubMed Statement sourceLedger id WG2013 | laboratory | electric toothbrush | 27 volunteers (brushing force); specimens (abrasion) — | Acknowledgements: "The authors wish to thank all volunteers for their participation in the study. We also thank the companies Biomed AG, Switzerland and Procter & Gamble GmbH, Germany, for providing the toothbrushes."Read on 2026-09-16 at the statement source | "The authors declare that they have no conflicts of interest." | laboratory · electric toothbrush · 27 volunteers (brushing force); specimens (abrasion) · not stated · basis: none available | not stated not stated (Biomed AG and Procter & Gamble provided the toothbrushes, per the acknowledgements)basis: none available | electric-vs-manual-toothbrush |
| The effect of different interdental cleaning devices on gingival bleedingRosema NA, 2011, J Int Acad PeriodontolPubMed Statement sourceLedger id ROSEMA2011 | RCT | water flosser | 108 adults 4 weeks | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, The Netherlands. (record) | RCT · water flosser · 108 adults / 4 weeks · not stated · basis: none available | not stated not statedbasis: none available | do-water-flossers-work |
| Instant dentin hypersensitivity relief of a new desensitizing dentifrice containing 8.0% arginine, a high cleaning calcium carbonate system and 1450 ppm fluoride: a 3-day clinical study in Chengdu, ChinaFu Y, 2010, Am J DentPubMed Statement sourceLedger id FU2010 | RCT | sensitivity | 122 subjects single application, then 3 days | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: The Key State Laboratory of Oral Diseases, Sichuan University, Chengdu, China. (record) | RCT · sensitivity · 122 subjects / single application, then 3 days · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpastesensitive-teeth-causes |
| The human oral microbiomeDewhirst FE, 2010, J BacteriolDOI PubMed Statement sourceLedger id D2010 | narrative review | microbiome | — — | Acknowledgments: "This work has been supported in part by contract U01 DE016937 and grants DE015847 and DE017106 from the National Institute of Dental and Craniofacial Research and a supplement to grant DE016937 from the American Recovery…Acknowledgments: "This work has been supported in part by contract U01 DE016937 and grants DE015847 and DE017106 from the National Institute of Dental and Craniofacial Research and a supplement to grant DE016937 from the American Recovery and Reinvestment Act of 2009."Read on 2026-09-16 at the statement source | No statement in the paper | narrative review · microbiome · — · public/charity · basis: funding statement | public/charity National Institute of Dental and Craniofacial Research (per the acknowledgments)basis: funding statement | oral-microbiome |
| Effect of a dental water jet with orthodontic tip on plaque and bleeding in adolescent patients with fixed orthodontic appliancesSharma NC, 2008, Am J Orthod Dentofacial OrthopDOI PubMed Statement sourceLedger id SH2008 | RCT | water flosser | 106 adolescents 4 weeks | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: BioSci Research Canada Ltd., Mississauga, Ontario, Canada. (record) | RCT · water flosser · 106 adolescents / 4 weeks · not stated · basis: none available | not stated not statedbasis: none available | do-water-flossers-work |
| The erosive potential of flavoured sparkling water drinksBrown CJ, 2007, Int J Paediatr DentDOI PubMed Statement sourceLedger id B2007 | laboratory | erosion | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: School of Dentistry, University of Birmingham and Birmingham Dental Hospital, Birmingham, UK. (record) | laboratory · erosion · — · not stated · basis: none available | not stated not statedbasis: none available | enamel-erosion-causes |
| Potassium containing toothpastes for dentine hypersensitivityPoulsen S, 2006, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id POULSEN2006 | systematic review | sensitivity | 6 trials in the meta-analysis 6 to 8 weeks | "Internal sources: Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark. External sources: No sources of support supplied"Read on 2026-09-23 at the statement source | "One of the review authors, Sven Poulsen (SP), was rewarded a prize from Zendium Inc., Denmark in 1997." | systematic review · sensitivity · 6 trials in the meta-analysis / 6 to 8 weeks · public/charity · basis: funding statement | public/charity Royal Dental College, University of Aarhus (internal source)basis: funding statement | sensitive-teeth-toothpaste |
| Tongue scraping for treating halitosisOuthouse TL, 2006, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id O2006 | systematic review | tongue scraping | 2 trials, 40 participants single sessions; withdrawn by Cochrane in 2016 | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled) | systematic review · tongue scraping · 2 trials, 40 participants / single sessions; withdrawn by Cochrane in 2016 · not stated · basis: none available | not stated not statedbasis: none available | tongue-scraping |
| Comparison of irrigation to floss as an adjunct to tooth brushing: effect on bleeding, gingivitis, and supragingival plaqueBarnes CM, 2005, J Clin DentPubMed Statement sourceLedger id BARNES2005 | RCT | water flosser | 105 enrolled, 95 completed 28 days | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: UNMC College of Dentistry, Lincoln, NE, USA. (record) | RCT · water flosser · 105 enrolled, 95 completed / 28 days · not stated · basis: none available | not stated not statedbasis: none available | do-water-flossers-work |
| Brushing abrasion of softened and remineralised dentin: an in situ studyAttin T, 2004, Caries ResDOI PubMed Statement sourceLedger id ATTIN2004 | in situ | erosion | — — | Statement not readable (paywalled)Read on 2026-09-16 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Department of Operative Dentistry, Preventive Dentistry and Periodontology, Georg August University Göttingen, Göttingen, Germany. (record) | in situ · erosion · — · not stated · basis: none available | not stated not statedbasis: none available | enamel-erosion-causes |
| Supragingival calculus: formation and controlJin Y, 2002, Crit Rev Oral Biol MedDOI PubMed Statement sourceLedger id JY2002 | narrative review | calculus | — — | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled) | narrative review · calculus · — · not stated · basis: none available | not stated not statedbasis: none available | 48-hoursplaque-vs-tartar |
| The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries preventionHujoel PP, 1999, J Dent ResDOI PubMed Statement sourceLedger id H1999 | cohort | xylitol | 288 children re-examined 5 years after a 2-year gum programme | Statement not readable (paywalled)Read on 2026-09-15 at the statement source | Statement not readable (paywalled) | cohort · xylitol · 288 children re-examined / 5 years after a 2-year gum programme · not stated · basis: none available | not stated not statedbasis: none available | xylitol-for-teeth |
| Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastesWest NX, 1997, J Clin PeriodontolDOI PubMed Statement sourceLedger id WEST1997 | RCT | sensitivity | 120 subjects, 112 completed 6 weeks | Statement not readable (paywalled)Read on 2026-09-23 at the statement source | Statement not readable (paywalled)Affiliations on PubMed: Department of Restorative Dentistry (Periodontology), Bristol Dental School, UK. (record) | RCT · sensitivity · 120 subjects, 112 completed / 6 weeks · not stated · basis: none available | not stated not statedbasis: none available | sensitive-teeth-toothpaste |
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Cite this dataset
Archived on Zenodo with a DOI: 10.5281/zenodo.22879103 · this snapshot: v1, 21 September 2026, 68 papers.
Pollman J. Trial funding ledger: funding and competing-interest statements for oral-health trials, reviews and guidelines. Zenodo; 2026. doi:10.5281/zenodo.22879103
Copied
@dataset{pollman_trial_funding_ledger_2026,
author = {Pollman, Jose},
title = {Trial funding ledger: funding and competing-interest statements for oral-health trials, reviews and guidelines},
year = {2026},
publisher = {Zenodo},
version = {1},
doi = {10.5281/zenodo.22879103},
url = {https://doi.org/10.5281/zenodo.22879103}
}
The live table above may run ahead of the archived snapshot; the snapshot is the citable version.
Suggest a paper
Nothing is sent by this page. It writes out a note you can read, and your own mail client sends it if you click the email link. A suggestion is not a submission: the paper gets opened and its statements quoted before a row appears in the table, which is the only way a row is ever made. A paper we have recorded wrongly is as welcome here as one we have missed.
A DOI, a PubMed ID, or a pubmed.ncbi.nlm.nih.gov address. Required, because a paper cannot be read without one.
0 of 300 characters
How to read a funding statement
The commonest sentence in the table is a version of “the funder had no role in study design, data collection, analysis or the decision to publish”. It tells you something real: the sponsor did not sit in the analysis. It does not tell you who chose the comparator, the outcome or the non-inferiority margin, and those are decided before a trial starts, when the funder is very much in the room. Read it as a statement about the middle of a trial, not the beginning.
Author employment is a different disclosure from sponsorship, and the ledger keeps the two apart. A trial paid for by a company is one thing; a trial with company employees on the author list is another, and a paper can be both. Look for the initials in a competing-interests line — “JE, FM and ESc are employees of” — and then look at the author list of the systematic review that later pools the trial. The site’s own worked example is hydroxyapatite: three of the four human trials name the same manufacturer as funder or employer, and the review that pools them shares every one of its six authors with the 18-month trial it includes. The ledger shows that as two rows — P2023 and PW2024 — and the pattern is the point.
The absence of a statement is information too. A paper from 2013 with no funding line may simply predate the journal’s policy; a paper from 2019 without one is a choice. We record the absence as a literal — “No funding statement in the paper” — rather than guessing, and we record a paywall as a paywall. A sponsor-funded trial whose funding line we could not read is not evidence of anything except that we could not read it.
What this ledger cannot tell you
Funding is not fraud. Manufacturer-funded trials in this table were, as far as the abstracts and papers show, competently run; some are the only trials of their kind. Unfunded trials can be small, short and badly blinded, and several of the papers with “none declared” are exactly that. The ledger records disclosure, not quality; the quality is argued page by page, in the articles that cite each paper, with the trial’s own numbers. Nor does the ledger rank anything: the rows sort by year, topic or funder type, and that is all the ordering there is. Where a statement stayed unreadable it is a fact about publishing, not about the paper: the journals concerned are Acta Odontol Scand, Am J Dent, Am J Orthod Dentofacial Orthop, Caries Res, Cochrane Database Syst Rev, Complement Ther Med, Crit Rev Oral Biol Med, Evid Based Dent, Int J Paediatr Dent, J Breath Res, J Clin Dent, J Clin Periodontol, J Dent, J Dent Res, J Evid Based Dent Pract, J Int Acad Periodontol, whose full text sits behind a paywall or behind a site that refuses automated reading.
How a paper gets in
Someone opens the paper. The funding statement and the competing-interests statement are copied word for word, in quotation marks. Where they were read and the date they were read on are recorded with them. Nothing is paraphrased and nothing is guessed, which is why a statement behind a paywall is recorded as a paywall rather than filled in.
The data file, its fields and the five fixed phrases are documented in the field guide.
Reuse the data
trials.json is published under CC BY 4.0: copy it, build on it, credit Know Your Mouth. The quoted statements remain the words of their authors and journals. Nothing you do on this page is sent anywhere; the table is plain HTML and the search runs in your browser.
This is a record of what papers disclose about their funding, not advice about any product or treatment. Nothing here is medical or dental advice; see a dentist about your own teeth.
Read next
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