Know Your Mouth

ToolsFunding ledger · 86 papers

Who paid for the trial?

Every human trial, systematic review and guideline this site relies on, one row per paper, with the funding statement and the authors’ declared interests quoted from the paper. Nothing summarised, nothing characterised.


This is the standing record behind every “who paid” sentence on the site: the papers we cite, with what each one says about its own money. Every statement is quoted, not summarised, so what you read here is what the authors wrote, down to the punctuation. A manufacturer paying for a trial does not make the trial wrong; it is context the reader is entitled to see next to the finding, which is the rule set out in how we review.

86papers
7manufacturer funder or manufacturer-employed authors
29public or charity funder
32no readable statement

none declared = the paper says it had no funding; not stated = the paper says nothing we could read; manufacturer-employed authors = a funding line, an interests line or the PubMed affiliation names the maker as an author’s employer (the basis is shown in the row).

The table is wider than the page. Scroll it sideways, or use the arrows; the funding and interests columns are to the right.

n / duration Funding statement, verbatim Competing interests, verbatim Used on
Enamel damage from tooth-whitening- a systematic review and meta-analysisMárton P, 2026, J DentDOI PubMed Statement sourceLedger id MARTON2026meta-analysiswhitening81 eligible laboratory studies; 9 pooled
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Prosthodontics, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Biophysics and Radiation Biology, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Oral Biology, Faculty of Dentistry Semmelweis University, Budapest, Hungary. | Centre for Translational Medicine, Semmelweis University, Budapest, Hungary; Department of Prosthodontics, Semmelweis University, Budapest, Hungary. Electronic address: abram.emese@semmelweis.hu. (record)meta-analysis · whitening · 81 eligible laboratory studies; 9 pooled · not stated · basis: none availablenot stated
not statedbasis: none available
do-whitening-strips-damage-enamel
The effects of using water flosser versus interdental brush on gingival health in patients with mandibular bonded retainer — a randomized controlled trialMasood Z, 2026, BMC Oral HealthDOI Statement sourceLedger id MASOOD2026RCTwater flosser
6 months
Funding: "Department of Surgery, Aga Khan University Hospital, Karachi." Acknowledgements: "We would like to acknowledge department of surgery, Aga Khan University Hospital, for funding the study."Read on 2026-09-16 at the statement source"The authors declare no competing interests."RCT · water flosser · — / 6 months · public/charity · basis: funding statementpublic/charity
Aga Khan University Hospital, Department of Surgerybasis: funding statement
not yet cited
Impact of sugar consumption on dental caries in children and adolescents: a systematic review of frequency versus quantityPombo-Lopes J, 2026, BMC Public HealthDOI PubMed Statement sourceLedger id SUG2026systematic reviewsugar37 studies, 59,383 participants
"This work was supported by FCT - Fundação para a Ciência e Tecnologia, I.P. by project reference UID/4585/2025 and DOI identifier https://doi.org/10.54499/UID/04585/2025."Read on 2026-09-15 at the statement source"The authors declare no competing interests."systematic review · sugar · 37 studies, 59,383 participants · public/charity · basis: funding statementpublic/charity
FCT - Fundação para a Ciência e Tecnologia (Portugal)basis: funding statement
can-teeth-remineralise
Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternativesWong AJ, 2026, Eur J PediatrDOI PubMed Statement sourceLedger id WONG2026systematic reviewhydroxyapatite122 studies, 20 with direct paediatric evidence
"No external funding was received to support this work."Read on 2026-09-16 at the statement source"The authors declare no competing interests."systematic review · hydroxyapatite · 122 studies, 20 with direct paediatric evidence · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpastehydroxyapatite-vs-fluoride-for-kids
Oral irrigator versus dental floss in orthodontic patients: a systematic review and meta-analysisYiamwattana I, 2026, Int J Dent HygDOI PubMed Statement sourceLedger id YIAM2026meta-analysiswater flosser4 trials
No funding statement in the paperRead on 2026-09-16 at the statement source"The authors declare no conflicts of interest."meta-analysis · water flosser · 4 trials · not stated · basis: none availablenot stated
not statedbasis: none available
not yet cited
Clinical and biochemical evaluation of oral irrigator effectiveness in fixed orthodontic treatment: a randomised clinical trialŞahin E, 2026, Int J Dent HygDOI PubMed Statement sourceLedger id SAHIN2026RCTwater flosser30 patients
8 weeks
Research funding: "Ondokuz Mayis Üniversitesi. Grant Number: PYO.DIŞ.1904.18.006"Read on 2026-09-16 at the statement source"The authors declare no conflicts of interest."RCT · water flosser · 30 patients / 8 weeks · public/charity · basis: funding statementpublic/charity
Ondokuz Mayis Universitybasis: funding statement
not yet cited
Hydrogen Peroxide-Free Color Correctors for Tooth Whitening in Adolescents and Young Adults: A Systematic Review of In Vitro and Clinical EvidenceBoruga M, 2025, Dent J (Basel)DOI PubMed Statement sourceLedger id BORUGA2025systematic reviewwhitening6 studies: 1 clinical trial, 5 laboratory
Funding: "The article processing charge was paid by the “Victor Babes” University of Medicine and Pharmacy Timisoara."Read on 2026-09-23 at the statement sourceConflicts of Interest: "The authors declare no conflicts of interest."systematic review · whitening · 6 studies: 1 clinical trial, 5 laboratory · public/charity · basis: funding statementpublic/charity
“Victor Babes” University of Medicine and Pharmacy Timisoara (article processing charge)basis: funding statement
do-whitening-strips-damage-enamel
The role of hydroxyapatite-based, fluoride-free toothpastes on the prevention and the remineralization of initial caries lesions: a systematic review and meta-analysisChatzidimitriou K, 2025, J DentDOI PubMed Statement sourceLedger id CHATZ2025meta-analysishydroxyapatite4 of 68 retrieved studies
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)meta-analysis · hydroxyapatite · 4 of 68 retrieved studies · not stated · basis: none availablenot stated
not statedbasis: none available
do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpastehydroxyapatite-vs-fluoride-for-kids
Do we have enough evidence to recommend hydroxyapatite toothpaste for preventing dental caries?Gugnani N, 2025, Evid Based DentDOI PubMed Statement sourceLedger id GUG2025commentaryhydroxyapatite
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)commentary · hydroxyapatite · — · not stated · basis: none availablenot stated
not statedbasis: none available
hydroxyapatite-toothpaste
Systematic Review of Experimental Gingivitis Induction Methods: Methodological Variations and Their Impact on Inflammation ProgressionJamjoom AG, 2025, Patient Prefer AdherenceDOI PubMed Statement sourceLedger id EG2025systematic reviewgingivitis10 studies
induction periods of 9 to 28 days
"This research received no external funding."Read on 2026-09-15 at the statement source"The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."systematic review · gingivitis · 10 studies / induction periods of 9 to 28 days · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
gum-disease-signs
Efficacy of a water flosser compared to an interdental brush on gingival bleeding and gingival abrasion: a 4 week randomized controlled trialMancinelli-Lyle D, 2025, Int J Dent HygDOI PubMed Statement sourceLedger id ML2025RCTwater flosser78 adults
4 weeks
"The first author, Mancinelli-Lyle, was an employee of Water Pik, Inc. when the study was conducted. Van der Weijden is the owner of Jardin B.V., which is the former owner of www.ragershop.com (a webshop for various brands of interdental…
"The first author, Mancinelli-Lyle, was an employee of Water Pik, Inc. when the study was conducted. Van der Weijden is the owner of Jardin B.V., which is the former owner of www.ragershop.com (a webshop for various brands of interdental brushes). The study was performed by the Department of Periodontology of ACTA with a commission from ACTA Dental Research B.V. In turn ACTA Research B.V. received financial support from Water Pik, Inc. Fort Collins, CO. USA, Water Pik, Inc. Fort Collins, CO. USA provided the study products. The research team at ACTA of Slot and van der Weijden has previously received either external advisor fees, lecturer fees or research grants from oral health care manufacturers. Those manufacturers included Colgate, Dentaid, GABA, Lactona, Oral-B, Philips, Procter & Gamble, Sara Lee, Sunstar, TePe, Unilever & Water Pik."Read on 2026-09-15 at the statement source
"The authors declare that there are no conflicts of interest."RCT · water flosser · 78 adults / 4 weeks · manufacturer-employed authors · basis: funding statementmanufacturer-employed authors
Water Pik, Inc.basis: funding statement
do-water-flossers-work
Salivary flow, tongue-coating burden, and morning breath odor: a cross-sectional studyPopa M, 2025, J Clin MedDOI PubMed Statement sourceLedger id POPA2025cross-sectionalbad breath92 young adults
"The Article Processing Charge (APC) was covered by ‘Victor Babeș’ University of Medicine and Pharmacy Timișoara. No external funding was received for the conduct of this research."Read on 2026-09-16 at the statement source"The authors declare no conflicts of interest."cross-sectional · bad breath · 92 young adults · none declared · basis: funding statementnone declared
none declared (the university paid the publication fee)basis: funding statement
bad-breath-causes
Opinion on hydroxyapatite (nano), submission IV, SCCS/1677/25Scientific Committee on Consumer Safety, 2025, European CommissionOfficial page Statement sourceLedger id SCCS2025guidelinehydroxyapatite
Public body — not applicableRead on 2026-09-15 at the statement sourcePublic body — not applicableguideline · hydroxyapatite · — · public/charity · basis: none availablepublic/charity
European Commission (SCCS)basis: none available
is-hydroxyapatite-toothpaste-safe-to-swallownano-vs-micro-hydroxyapatite
Oral health benefits and safety of xylitol and potential cardiovascular risk: questioning the validity of the model of Witkowski et al.Valentine GC, 2025, Eur Heart JDOI PubMed Statement sourceLedger id EHJL1letterxylitol
"G.C.V. is supported by a grant from the National Institutes of Health (K23 HD105929)."Read on 2026-09-16 at the statement source"All authors declare no disclosure of interest for this contribution."letter · xylitol · — · public/charity · basis: funding statementpublic/charity
National Institutes of Health (one author’s grant)basis: funding statement
xylitol-for-teeth
Survey methods contributing to the difference of dentin hypersensitivity prevalence among publications between 1998 and 2022: a research-on-research studyWang G, 2025, BMC Oral HealthDOI PubMed Statement sourceLedger id DH2025meta-analysissensitivity39 prevalence studies
"We would like to thank the support from Sichuan University and Luzhou government (2018 Sichuan University-Luzhou Municipal Government Strategic Cooperation Research (2018CDLZ-12))."Read on 2026-09-15 at the statement source"The authors declare no competing interests."meta-analysis · sensitivity · 39 prevalence studies · public/charity · basis: funding statementpublic/charity
Sichuan University and Luzhou governmentbasis: funding statement
sensitive-teeth-causes
Xylitol exposure and cardiovascular riskWölnerhanssen BK, 2025, Eur Heart JDOI PubMed Statement sourceLedger id EHJL2letterxylitol
No funding statement in the paperRead on 2026-09-16 at the statement source"B.K.W. and A.C.M.-G.: nothing to declare. A.A.: founder and major shareholder of CoreQuest and Iperboreal Pharma."letter · xylitol · — · not stated · basis: none availablenot stated
not statedbasis: none available
xylitol-for-teeth
Efficacy and safety of probiotic therapy for halitosis: a systematic review and meta-analysis of randomized controlled trialsYang Y, 2025, J Breath ResDOI PubMed Statement sourceLedger id PH2025meta-analysisprobiotics10 studies
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)meta-analysis · probiotics · 10 studies · not stated · basis: none availablenot stated
not statedbasis: none available
do-oral-probiotics-work
Clinical efficacy of vestibular incision subperiosteal tunnel access (VISTA) for the treatment of gingival recession: a systematic review and meta-analysisZhu Q, 2025, BMC Oral HealthDOI PubMed Statement sourceLedger id VISTA2025meta-analysisrecession14 studies, 226 patients
"Effect of non-impacted third molars on the periodontal health of adjacent teeth."Read on 2026-09-15 at the statement source"The authors declare no competing interests."meta-analysis · recession · 14 studies, 226 patients · not stated · basis: funding statementnot stated
Named as a project title only — funder not statedbasis: funding statement
receding-gums-causes
Over-the-counter products in tooth bleaching: A scoping reviewBarbosa LMM, 2024, J DentDOI PubMed Statement sourceLedger id BARBOSA2024systematic reviewwhitening88 studies
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Department of Restorative Dentistry, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil. | Nova Esperança School (Facene), João Pessoa, Paraíba, Brazil. | Dental Materials Division, Department of Restorative Dentistry, Piracicaba Dental School, State University of Campinas (FOP/UNICAMP), Piracicaba, São Paulo, Brazil. | Department of Dentistry, Federal University of Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil. | ATITUS Educação, Meridional Faculty, Passo Fundo, Rio Grande do Sul, Brazil. | Department of Restorative Dentistry, Federal University of Paraíba (UFPB), João Pessoa, Paraíba, Brazil. Electronic address: renally.lima@academico.ufpb.br. (record)systematic review · whitening · 88 studies · not stated · basis: none availablenot stated
not statedbasis: none available
do-whitening-strips-damage-enamel
The effectiveness of water jet flossing and interdental flossing for oral hygiene in orthodontic patients with fixed appliances: a randomized clinical trialAlMoharib HS, 2024, BMC Oral HealthDOI Statement sourceLedger id ALMO2024RCTwater flosser
"This study was funded by the Saudi Society of Periodontology, Riyadh, Saudi Arabia."Read on 2026-09-16 at the statement source"The authors declare no competing interests."RCT · water flosser · — · public/charity · basis: funding statementpublic/charity
Saudi Society of Periodontologybasis: funding statement
not yet cited
Should we wait to brush our teeth? A scoping review regarding dental caries and erosive tooth wearFernández CE, 2024, Caries ResDOI PubMed Statement sourceLedger id FERN2024systematic reviewerosion
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Cariology Unit, Department of Oral Rehabilitation, Faculty of Dentistry, University of Talca, Talca, Chile. (record)systematic review · erosion · — · not stated · basis: none availablenot stated
not statedbasis: none available
enamel-erosion-causes
The effect of oil pulling in comparison with chlorhexidine and other mouthwash interventions in promoting oral health: a systematic review and meta-analysisJong FJX, 2024, Int J Dent HygDOI PubMed Statement sourceLedger id OP2024meta-analysisoil pulling25 trials, 1,184 participants
7 to 45 days
"The authors declare no funds or financial support."Read on 2026-09-15 at the statement source"The authors declare no competing interests."meta-analysis · oil pulling · 25 trials, 1,184 participants / 7 to 45 days · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
oil-pulling-does-it-work
Efficacy of Probiotic Consumption on Oral Outcomes in Children and/or Adolescents: A Meta-AnalysisMayta-Tovalino F, 2024, Int Dent JDOI PubMed Statement sourceLedger id PB2024meta-analysisprobiotics19 RCTs, 2,622 children and adolescents
0.2 months and longer
"This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors."Read on 2026-09-15 at the statement source"The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper."meta-analysis · probiotics · 19 RCTs, 2,622 children and adolescents / 0.2 months and longer · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
do-oral-probiotics-work
Clinical evidence of caries prevention by hydroxyapatite: an updated systematic review and meta-analysisPawinska M, 2024, J DentDOI PubMed Statement sourceLedger id PW2024meta-analysishydroxyapatite5 clinical and 8 in situ trials
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)meta-analysis · hydroxyapatite · 5 clinical and 8 in situ trials · not stated · basis: none availablenot stated
not statedbasis: none available
do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpaste
The effect of xylitol chewing gums and candies on caries occurrence in children: a systematic review with special reference to caries level at study baselinePienihäkkinen K, 2024, Eur Arch Paediatr DentDOI PubMed Statement sourceLedger id EAPD2024systematic reviewxylitol15 articles; ten gum studies
"Open Access funding provided by University of Turku (including Turku University Central Hospital)."Read on 2026-09-16 at the statement source"The authors report no conflict of interest."systematic review · xylitol · 15 articles; ten gum studies · public/charity · basis: funding statementpublic/charity
University of Turku (open-access fee)basis: funding statement
xylitol-for-teeth
Do chewing gums and sweets containing xylitol prevent caries in children?Ramasubbu D, 2024, Evid Based DentDOI PubMed Statement sourceLedger id EBD2024commentaryxylitol
"Open Access funding provided by the IReL Consortium."Read on 2026-09-16 at the statement source"The authors declare no competing interests."commentary · xylitol · — · public/charity · basis: funding statementpublic/charity
IReL Consortium (open-access fee)basis: funding statement
xylitol-for-teeth
Xylitol is prothrombotic and associated with cardiovascular riskWitkowski M, 2024, Eur Heart JDOI PubMed Statement sourceLedger id EHJ2024cohortxylitol3,306 patients (discovery and validation cohorts); 10 healthy volunteers (xylitol ingestion)
3-year follow-up
"This work is supported by grants from the NIH and Office of Dietary Supplements (P01 HL147823, R01 HL103866), the Deutsche Forschungsgemeinschaft (WI 5229/1-1), and the Deutsche Stifterverband (S0199/10098/2023)."Read on 2026-09-16 at the statement source
"S.L.H. and Z.W. report being named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. S.L.H. and Z.W. also report having received royalty payments for…
"S.L.H. and Z.W. report being named as co-inventors on pending and issued patents held by the Cleveland Clinic relating to cardiovascular diagnostics and therapeutics. S.L.H. and Z.W. also report having received royalty payments for inventions or discoveries related to cardiovascular diagnostics or therapeutics from Cleveland Heart Lab, a fully owned subsidiary of Quest Diagnostics, and Procter & Gamble. S.L.H. is a paid consultant for Zehna Therapeutics and formerly for Proctor & Gamble; has received research funds from Zehna Therapeutics, Proctor & Gamble, Pfizer, and Roche Diagnostics; and is eligible to receive royalty payments for inventions or discoveries related to cardiovascular diagnostics and therapeutics from Zehna Therapeutics. W.H.W.T. reports being a consultant for Sequana Medical A.G., Owkin Inc., Relypsa Inc., and PreCardiac Inc. and having received honorarium from Springer Nature for authorship/editorship and American Board of Internal Medicine for exam writing committee participation—all unrelated to the subject and contents of this paper. The other authors have reported that they have no relationships relevant to the contents of this paper to disclose."
cohort · xylitol · 3,306 patients (discovery and validation cohorts); 10 healthy volunteers (xylitol ingestion) / 3-year follow-up · public/charity · basis: funding statementpublic/charity
NIH and Office of Dietary Supplements; Deutsche Forschungsgemeinschaft; Deutsche Stifterverbandbasis: funding statement
xylitol-for-teeth
The effectiveness of oral irrigators on periodontal health status and oral hygiene of orthodontic patients: a systematic review and meta-analysisZarei Z, 2024, BMC Oral HealthDOI Statement sourceLedger id ZAREI2024meta-analysiswater flosser7 trials
"Have no financial or non- financial support."Read on 2026-09-16 at the statement source"The authors declare no competing interests."meta-analysis · water flosser · 7 trials · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
not yet cited
Tongue-coating microbial and metabolic characteristics in halitosisZhang Y, 2024, J Dent ResDOI PubMed Statement sourceLedger id JDR2024cross-sectionalbad breath
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Department of Preventive Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. (record)cross-sectional · bad breath · — · not stated · basis: none availablenot stated
not statedbasis: none available
bad-breath-causes
In Vitro Evaluation of Tooth-Whitening Potential of Peroxide-Free OTC Dental Bleaching AgentsGrillon M, 2023, Dent J (Basel)DOI PubMed Statement sourceLedger id GRILLON2023laboratorywhitening80 bovine incisors
up to 200 minutes of product exposure
Funding: "No grant was received for this study; the products were purchased and paid for by our division (Division of Cariology and Endodontology, Section of Dental Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland)."Read on 2026-09-23 at the statement sourceConflicts of Interest: "The authors declare no conflict of interest."laboratory · whitening · 80 bovine incisors / up to 200 minutes of product exposure · public/charity · basis: funding statementpublic/charity
University of Geneva (the authors’ own division)basis: funding statement
do-whitening-strips-damage-enamel
Clinical evidence of biomimetic hydroxyapatite in oral care products for reducing dentin hypersensitivity: an updated systematic review and meta-analysisLimeback H, 2023, Biomimetics (Basel)DOI PubMed Statement sourceLedger id LIME2023meta-analysishydroxyapatite
"This research received no external funding."Read on 2026-09-16 at the statement source"J.E. and F.M. are senior scientists and employees of Dr. Kurt Wolff GmbH & Co. KG in Germany."meta-analysis · hydroxyapatite · — · manufacturer-employed authors · basis: competing-interests statementmanufacturer-employed authors
Dr. Kurt Wolff GmbH & Co. KGbasis: competing-interests statement
do-dentists-recommend-hydroxyapatitesensitive-teeth-toothpaste
Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trialPaszynska E, 2023, Front Public HealthDOI PubMed Statement sourceLedger id P2023non-inferiority RCThydroxyapatite189 adults
18 months
"This research was funded by Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany, and both universities, the Poznan University of Medical Sciences in Poznan and the Medical University in Bialystok, Poland."Read on 2026-09-15 at the statement source
"JE, FM, and ESc are employees of Dr. Kurt Wolff GmbH and Co. KG, Bielefeld, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a…
"JE, FM, and ESc are employees of Dr. Kurt Wolff GmbH and Co. KG, Bielefeld, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."
non-inferiority RCT · hydroxyapatite · 189 adults / 18 months · manufacturer · basis: funding statementmanufacturer
Dr. Kurt Wolff GmbH & Co. KG, with two universitiesbasis: funding statement
do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpastenano-vs-micro-hydroxyapatite
Formulations of desensitizing toothpastes for dentin hypersensitivity: a scoping reviewMartins CC, 2022, J Appl Oral SciDOI PubMed Statement sourceLedger id MARTINS2022systematic reviewsensitivity138 RCTs
Funding: "CCM received a postdoctoral fellowship from CAPES (Coordination for the Improvement of Higher Educational Personnel, Ministry of Education, Brazil, process #88881.119166/2016-01), during her post-doctoral studies at McMaster…
Funding: "CCM received a postdoctoral fellowship from CAPES (Coordination for the Improvement of Higher Educational Personnel, Ministry of Education, Brazil, process #88881.119166/2016-01), during her post-doctoral studies at McMaster University. RTF was supported by CAPES. JJR was supported by a PhD training award from the NCMIC Foundation."Read on 2026-09-23 at the statement source
Conflict of interest: "The authors declare no potential conflicts of interest regarding the authorship and/or publication of this article."systematic review · sensitivity · 138 RCTs · public/charity · basis: funding statementpublic/charity
CAPES (Brazilian Ministry of Education); NCMIC Foundationbasis: funding statement
sensitive-teeth-toothpaste
Health Products Compliance GuidanceFederal Trade Commission, 2022, FTCOfficial page Statement sourceLedger id FTC2022guidelinehealth claims
Public body — not applicableRead on 2026-09-15 at the statement sourcePublic body — not applicableguideline · health claims · — · public/charity · basis: none availablepublic/charity
Federal Trade Commissionbasis: none available
reference-checker
Effectiveness of oil pulling for improving oral health: a meta-analysisPeng TR, 2022, Healthcare (Basel)DOI PubMed Statement sourceLedger id OP2022meta-analysisoil pulling9 RCTs
Funding: "This research received no external funding." Acknowledgments: "This study was supported by grants from the Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (TCRD-TPE-111-54)."Read on 2026-09-15 at the statement source"The authors declare no conflict of interest."meta-analysis · oil pulling · 9 RCTs · public/charity · basis: funding statementpublic/charity
Taipei Tzu Chi Hospital (per the acknowledgements)basis: funding statement
oil-pulling-does-it-work
The effect of mechanical tongue cleaning on oral malodor and tongue coatingChoi HN, 2021, Int J Environ Res Public HealthDOI PubMed Statement sourceLedger id CHOI2021RCTtongue scrapingthree groups: toothbrush, scraper, both
single session
"This research received no external funding."Read on 2026-09-16 at the statement source"The authors declare no conflict of interest."RCT · tongue scraping · three groups: toothbrush, scraper, both / single session · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
tongue-scraping
Efficacy of a zinc lactate mouthwash and tongue scraping in the reduction of intra-oral halitosis: a single-blind, controlled, crossover clinical trial — a pilot studyDudzik A, 2021, J Clin MedDOI PubMed Statement sourceLedger id DUD2021RCTtongue scraping60 volunteers
two 14-day protocols
"This research received no external funding."Read on 2026-09-16 at the statement source"The authors declare no conflict of interest."RCT · tongue scraping · 60 volunteers / two 14-day protocols · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
tongue-scraping
Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysisLimeback H, 2021, Can J Dent HygPubMed Statement sourceLedger id LIME2021meta-analysishydroxyapatite
No funding statement in the paperRead on 2026-09-16 at the statement sourceNo statement in the paperAffiliations on PubMed: Senior scientist, Oral care, Dr. Kurt Wolff GmbH & Co. KG, Research Department, Bielefeld, Germany (Enax J; Meyer F) (record)meta-analysis · hydroxyapatite · — · manufacturer-employed authors · basis: affiliation (PubMed)manufacturer-employed authors
Dr. Kurt Wolff GmbH & Co. KGbasis: affiliation (PubMed)
do-dentists-recommend-hydroxyapatite
Delivering better oral health: an evidence-based toolkit for preventionOffice for Health Improvement and Disparities, 2021, gov.ukOfficial page Statement sourceLedger id DBOHguidelinefluoride
Public body — not applicableRead on 2026-09-15 at the statement sourcePublic body — not applicableguideline · fluoride · — · public/charity · basis: none availablepublic/charity
Office for Health Improvement and Disparities (UK government)basis: none available
do-whitening-strips-damage-enamelhydroxyapatite-vs-fluoride-for-kidsis-hydroxyapatite-toothpaste-safe-to-swallowsensitive-teeth-causessensitive-teeth-toothpastetoothpaste-ingredient-decoder
Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trialPaszynska E, 2021, Sci RepDOI PubMed Statement sourceLedger id P2021non-inferiority RCThydroxyapatite207 children
336 days
"This study was funded by Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany. The funders had no role in recruiting, conduction of the study, data collection, and statistical analysis."Read on 2026-09-15 at the statement source"The authors declare no competing interest."non-inferiority RCT · hydroxyapatite · 207 children / 336 days · manufacturer · basis: funding statementmanufacturer
Dr. Kurt Wolff GmbH & Co. KGbasis: funding statement
do-dentists-recommend-hydroxyapatitehydroxyapatite-vs-fluoride-for-kidsnano-vs-micro-hydroxyapatite
Changes in tonsillolith characteristics detected in a follow-up CT studyYamashita K, 2021, BMC Oral HealthDOI PubMed Statement sourceLedger id TS2021cohorttonsil stones326 CT scan pairs
follow-up CT examinations
"This study received no funding with respect to study design; the collection, analysis and interpretation of subject's data; or writing the manuscript."Read on 2026-09-15 at the statement source"The authors declare that they have no competing interests."cohort · tonsil stones · 326 CT scan pairs / follow-up CT examinations · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
bad-breath-causes
Desensitizing Toothpastes for Dentin Hypersensitivity: A Network Meta-analysisMartins CC, 2020, J Dent ResDOI PubMed Statement sourceLedger id MARTINS2020meta-analysissensitivity125 RCTs, 12,541 patients
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Pediatric Dentistry and Orthodontics, Federal University of Minas Gerais, Belo Horizonte, Brazil. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Pediatric Dentistry and Orthodontics, Federal University of Minas Gerais, Belo Horizonte, Brazil. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Family Medicine; McMaster University, Hamilton, ON, Canada. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Evidence-Based Social Science Research Center, School of Public Health, Lanzhou University, Lanzhou, China. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Oral and Craniofacial Health Science, School of Dentistry, University of North Carolina at Chapel Hill, NC, USA. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Dentistry, State University of Paraíba, Campina Grande, Brazil. | Department of Clinical, Pathology and Oral Surgery, Federal University of Minas Gerais, Belo Horizonte, Brazil. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | School of Medicine, Universidad de los Andes, Bogotá, Colombia. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. | Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada. (record)meta-analysis · sensitivity · 125 RCTs, 12,541 patients · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste
Mouthwash with alcohol and oral carcinogenesis: systematic review and meta-analysisAceves Argemí R, 2020, J Evid Based Dent PractDOI PubMed Statement sourceLedger id ACEVES2020meta-analysismouthwash14 articles (11 case-control, 3 clinical)
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)meta-analysis · mouthwash · 14 articles (11 case-control, 3 clinical) · not stated · basis: none availablenot stated
not statedbasis: none available
is-mouthwash-bad-for-you
Risk-based, 6-monthly and 24-monthly dental check-ups for adults: the INTERVAL three-arm RCTClarkson JE, 2020, Health Technol AssessDOI PubMed Statement sourceLedger id C2020RCTrecall interval2,372 adults
4 years
"This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme [project numbers 06/35/05 (Phase I) and 06/35/99 (Phase II)] and will be published in full in Health Technology…
"This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme [project numbers 06/35/05 (Phase I) and 06/35/99 (Phase II)] and will be published in full in Health Technology Assessment; Vol. 24, No. 60. See the NIHR Journals Library website for further project information."Read on 2026-09-15 at the statement source
"Nigel B Pitts consults for Colgate (Colgate-Palmolive Company, New York, NY, USA) and GlaxoSmithKline plc (Brentford, UK) (toothpaste manufacturers) and was also a co-applicant on the National Institute for Health Research (NIHR) Health…
"Nigel B Pitts consults for Colgate (Colgate-Palmolive Company, New York, NY, USA) and GlaxoSmithKline plc (Brentford, UK) (toothpaste manufacturers) and was also a co-applicant on the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) Improving the Quality of Dentistry trial of dental scale and polish. Craig R Ramsay is a member of the NIHR HTA General Board. John DT Norrie reports grants from the University of Aberdeen and grants from the University of Edinburgh during the conduct of the study, and declares membership of the following NIHR boards: CPR decision making committee, HTA Commissioning Board, HTA Commissioning Sub-Board (Expression of Interest), HTA Funding Boards Policy Group, HTA General Board, HTA Post-Board funding teleconference, NIHR Clinical Trials Unit Standing Advisory Committee, NIHR HTA and Efficacy and Mechanism Evaluation Editorial Board and the Pre-exposure Prophylaxis Impact Review Panel. Gail Douglas reports that she is employed full time by the University of Leeds; 1 day of her time is bought out by Public Health England to assist with academic input to the dental epidemiology programme for England. She is also currently President of the British Association for the Study of Community Dentistry, a professional organisation principally for those working in the field of dental public health or allied areas."
RCT · recall interval · 2,372 adults / 4 years · public/charity · basis: funding statementpublic/charity
NIHR Health Technology Assessment programmebasis: funding statement
what-a-dental-cleaning-does
Recall intervals for oral health in primary care patientsFee PA, 2020, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id F2020systematic reviewrecall interval2 trials, 1,736 participants
2 to 4 years
"Internal sources: School of Dentistry, The University of Manchester, UK. Scottish Executive, UK. University College Cork, Ireland. MAHSC, UK. Cochrane Oral Health is supported by the Manchester Academic Health Sciences Centre (MAHSC) and…
"Internal sources: School of Dentistry, The University of Manchester, UK. Scottish Executive, UK. University College Cork, Ireland. MAHSC, UK. Cochrane Oral Health is supported by the Manchester Academic Health Sciences Centre (MAHSC) and the NIHR Manchester Biomedical Research Centre. External sources: Cochrane Fellowship - Health Research Board, Ireland. Department of Health Cochrane Review Incentive Scheme, UK. National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the authors and do not necessarily reflect those of the Evidence Synthesis Programme, the NIHR, NHS, or the Department of Health and Social Care. Cochrane Oral Health Group Global Alliance, UK. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors in the last two years have been the American Association of Public Health Dentistry, USA; AS-Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Swiss Society of Endodontology, Switzerland."Read on 2026-09-15 at the statement source
"PF: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. PR: no interests to declare. HW: was involved with one of…
"PF: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. PR: no interests to declare. HW: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. Professor Worthington is a Co-ordinating Editor with Cochrane Oral Health. JC: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. Professor Clarkson is a Co-ordinating Editor with Cochrane Oral Health. DB: was involved with one of the included studies (INTERVAL 2020), but was not involved with the data extraction from this study or assessment of its risk of bias for this review. PB: no interests to declare."
systematic review · recall interval · 2 trials, 1,736 participants / 2 to 4 years · public/charity · basis: funding statementpublic/charity
NIHR, via Cochrane Infrastructure funding to Cochrane Oral Healthbasis: funding statement
what-a-dental-cleaning-does
Does delayed toothbrushing after the consumption of erosive foodstuffs or beverages decrease erosive tooth wear? A systematic review and meta-analysisHong DW, 2020, Clin Oral InvestigDOI PubMed Statement sourceLedger id DT2020meta-analysiserosion12 in situ and in vitro studies
"This study was partially supported by the Guiding Project for Science and Technology of Fujian Province (2018Y0029), and the Joint Fund for Scientific and Technological Innovation of Fujian Province (2019Y9030)."Read on 2026-09-15 at the statement source"The authors declare that they have no conflict of interest."meta-analysis · erosion · 12 in situ and in vitro studies · public/charity · basis: funding statementpublic/charity
Fujian Province science and technology fundsbasis: funding statement
enamel-erosion-causes
Dental checks: intervals between oral health reviews (CG19) and 2020 surveillance decisionNICE, 2020, NICEOfficial page Statement sourceLedger id NICE19guidelinerecall interval
Public body — not applicableRead on 2026-09-15 at the statement sourcePublic body — not applicableguideline · recall interval · — · public/charity · basis: none availablepublic/charity
NICEbasis: none available
what-a-dental-cleaning-does
The effect of oil pulling with coconut oil to improve dental hygiene and oral health: a systematic reviewWoolley J, 2020, HeliyonDOI PubMed Statement sourceLedger id OP2020systematic reviewoil pulling4 trials, 182 participants
7 to 30 days
"This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors."Read on 2026-09-16 at the statement source"The authors declare no conflict of interest."systematic review · oil pulling · 4 trials, 182 participants / 7 to 30 days · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
oil-pulling-does-it-work
Network meta-analysis on the effect of desensitizing toothpastes on dentine hypersensitivityHu ML, 2019, J DentDOI PubMed Statement sourceLedger id HU2019meta-analysissensitivity30 RCTs
2, 4 and 8 weeks
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing, 100081, China. Electronic address: dentalhan@126.com. (record)meta-analysis · sensitivity · 30 RCTs / 2, 4 and 8 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpastesensitive-teeth-causes
Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysisde Melo Alencar C, 2019, J DentDOI PubMed Statement sourceLedger id ALENCAR2019meta-analysissensitivity6 RCTs
4 weeks
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: School of Dentistry, Federal University of Para, Belém, PA, Brazil. | School of Dentistry, Federal University of Para, Belém, PA, Brazil. | School of Dentistry, Federal University of Para, Belém, PA, Brazil. | School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. | School of Dentistry, Federal University of Para, Belém, PA, Brazil. Electronic address: cecymsilva@gmail.com. | School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. (record)meta-analysis · sensitivity · 6 RCTs / 4 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste
Efficacy of 8% arginine on dentin hypersensitivity: A multicenter clinical trial in 273 patients over 24 weeksHirsiger C, 2019, J DentDOI PubMed Statement sourceLedger id HIRSIGER2019RCTsensitivity297 randomised, 273 completed
24 weeks
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: constanze.hirsiger@zzm.uzh.ch. | Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: patrick.schmidlin@zzm.uzh.ch. | Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address: mary.michaelis@uk-halle.de. | Department of Pediatric Dentistry, University School of Dentistry, Liebigstraße 10 - 14, 04103, Leipzig, Germany. Electronic address: kizhk@medizin.uni-leipzig.de. | Clinic of Preventive Dentistry, Periodontology and Cariology, Center of Dental Medicine, University of Zürich, Plattenstrasse 33, 8032, Zürich Switzerland. Electronic address: thomas.attin@zzm.uzh.ch. | Department of Statistics, Ludwig-Maximilian-University, Ludwigstrasse 33, 80539, Munich, Germany. Electronic address: christian.heumann@stat.uni-muenchen.de. | Univ Clermont Auvergne, UFR d'Odontologie; Centre de Recherche en Odontologie Clinique EA 4847, Rue de Braga 2, F-63000 Clermont-Ferrand; CHU Estaing Clermont-Ferrand, Service d'Odontologie, Hôtel-, F-63001, Clermont-Ferrand, France. Electronic address: sophie.domejean@uca.fr. | Department of Operative Dentistry and Periodontology, School of Dental Medicine, Martin-Luther-University, Magdeburger Strasse 16, 06120, Halle, Germany. Electronic address: christian.gernhardt@uk-halle.de. (record)RCT · sensitivity · 297 randomised, 273 completed / 24 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste
Comparative efficacy of a hydroxyapatite and a fluoride toothpaste for prevention and remineralization of dental caries in childrenAmaechi BT, 2019, BDJ OpenDOI PubMed Statement sourceLedger id A2019in situhydroxyapatite30 adults
14 days per arm
No funding statement in the paperRead on 2026-09-15 at the statement source"The authors declare no competing interests."in situ · hydroxyapatite · 30 adults / 14 days per arm · not stated · basis: competing-interests statementnot stated
not statedbasis: competing-interests statement
do-dentists-recommend-hydroxyapatitehydroxyapatite-toothpaste
Home use of interdental cleaning devices and toothbrushing and their role in disease preventionGallie A, 2019, Evid Based DentDOI PubMed Statement sourceLedger id EBD2019commentaryflossing
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: King’s College London, London, UK. (record)commentary · flossing · — · not stated · basis: none availablenot stated
not statedbasis: none available
what-the-flossing-evidence-actually-measured
Occurrence and predictors of gingivitis and supragingival calculus in a population of Brazilian adultsHaas AN, 2019, Braz Oral ResDOI PubMed Statement sourceLedger id PA2019cross-sectionalcalculus758 adults aged 35 to 59
No funding statement in the paperRead on 2026-09-15 at the statement source"The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript."cross-sectional · calculus · 758 adults aged 35 to 59 · not stated · basis: competing-interests statementnot stated
not statedbasis: competing-interests statement
48-hoursplaque-vs-tartar
Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: a randomized, controlled 6-month trialSchlagenhauf U, 2019, J Investig Clin DentDOI PubMed Statement sourceLedger id S2019RCThydroxyapatite147 orthodontic patients
6 months
"The study was exclusively funded by Dr. Kurt Wolff GmbH & Co. KG, Bielefeld, Germany"Read on 2026-09-15 at the statement sourceNo statement in the paperRCT · hydroxyapatite · 147 orthodontic patients / 6 months · manufacturer · basis: funding statementmanufacturer
Dr. Kurt Wolff GmbH & Co. KGbasis: funding statement
do-dentists-recommend-hydroxyapatitenano-vs-micro-hydroxyapatite
Home use of interdental cleaning devices, in addition to toothbrushing, for preventing and controlling periodontal diseases and dental cariesWorthington HV, 2019, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id W2019systematic reviewflossing35 trials, 3,929 adults
4 weeks to 6 months
"Internal sources: School of Dentistry, The University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), the NIHR Manchester Biomedical Research Centre, UK. External sources: National Institute for Health Research (NIHR),…
"Internal sources: School of Dentistry, The University of Manchester, Manchester Academic Health Sciences Centre (MAHSC), the NIHR Manchester Biomedical Research Centre, UK. External sources: National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health. Cochrane Oral Health Global Alliance, Other. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors over the past year have been the American Association of Public Health Dentistry, USA; AS-Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and the Swiss Society for Endodontology, Switzerland."Read on 2026-09-15 at the statement source
"Helen Worthington: none known. Co-ordinating Editor of Cochrane Oral Health. Author on one included study (assessed by other review authors). Laura MacDonald: none known. Managing Editor with Cochrane Oral Health. Tina Poklepovic Pericic:…
"Helen Worthington: none known. Co-ordinating Editor of Cochrane Oral Health. Author on one included study (assessed by other review authors). Laura MacDonald: none known. Managing Editor with Cochrane Oral Health. Tina Poklepovic Pericic: none known. Dario Sambunjak: none known. Trevor Johnson: none known. Editor with Cochrane Oral Health. Pauline Imai: none known. Author on one included study (assessed by other review authors). Jan Clarkson: none known. Co-ordinating Editor of Cochrane Oral Health."
systematic review · flossing · 35 trials, 3,929 adults / 4 weeks to 6 months · public/charity · basis: funding statementpublic/charity
NIHR, via Cochrane Infrastructure funding to Cochrane Oral Healthbasis: funding statement
do-water-flossers-workhow-often-should-you-flosswhat-the-flossing-evidence-actually-measured
Sugar restriction for caries prevention: amount and frequency. Which is more important?van Loveren C, 2019, Caries ResDOI PubMed Statement sourceLedger id VL2019narrative reviewsugar
No funding statement in the paperRead on 2026-09-15 at the statement source"The author declares no conflicts of interest."narrative review · sugar · — · not stated · basis: competing-interests statementnot stated
not statedbasis: competing-interests statement
can-teeth-remineralise
Home-based chemically-induced whitening (bleaching) of teeth in adultsEachempati P, 2018, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id EACH2018systematic reviewwhitening71 trials; 26 against placebo (1,398 participants)
2 weeks to 6 months
Internal sources: "Faculty of Dentistry, Melaka‐Manipal Medical College, Manipal University, Melaka Campus, Malaysia." External sources: "National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via…
Internal sources: "Faculty of Dentistry, Melaka‐Manipal Medical College, Manipal University, Melaka Campus, Malaysia." External sources: "National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health. Cochrane Oral Health Global Alliance, Other. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships‐alliances). Contributors over the past year have been the American Association of Public Health Dentistry, USA; AS‐Akademie, Germany; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; NHS Education for Scotland, UK; and the Swiss Society for Endodontology, Switzerland."Read on 2026-09-23 at the statement source
Declarations of interest: "Prashanti Eachempati: none known. Sumanth Kumbargere Nagraj: none known. Salian Kiran Kumar Krishanappa: none known. Puneet Gupta: none known. Ibrahim Ethem Yaylali: none known."systematic review · whitening · 71 trials; 26 against placebo (1,398 participants) / 2 weeks to 6 months · public/charity · basis: funding statementpublic/charity
NIHR (UK), via Cochrane infrastructure funding; Cochrane Oral Health Global Alliancebasis: funding statement
do-whitening-strips-damage-enamel
Effect of desensitizing toothpastes on dentine hypersensitivity: A systematic review and meta-analysisHu ML, 2018, J DentDOI PubMed Statement sourceLedger id HU2018meta-analysissensitivity53 RCTs, 4,796 patients
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. | Dental Medical Devices Testing Center, Dental Materials Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081, China. Electronic address: linhong611@163.com. (record)meta-analysis · sensitivity · 53 RCTs, 4,796 patients · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste
Evaluation of the addition of a water flosser to manual brushing on gingival healthGoyal CR, 2018, J Clin DentPubMed Statement sourceLedger id G2018RCTwater flosser72 adults
4 weeks
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: All Sum Research Center, Mississauga, Ontario, Canada. | All Sum Research Center, Mississauga, Ontario, Canada. | Reinhard Schuller Consulting, Toronto, Ontario, Canada. | Water Pik, Inc., Fort Collins, CO., USA. (record)RCT · water flosser · 72 adults / 4 weeks · manufacturer-employed authors · basis: affiliation (PubMed)manufacturer-employed authors
Water Pik, Inc.basis: affiliation (PubMed)
do-water-flossers-work
Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trialInvernici MM, 2018, J Clin PeriodontolDOI PubMed Statement sourceLedger id I2018RCTprobiotics41 patients
90 days
"The study was supported by the National Council for Scientific and Technological Development (CNPq - process #480982/2013-9) awarded to Michel R. Messora. DuPont de Nemours & Co. Danisco Sweeteners Oy (Kantvik, Finland) donated the probiotics."Read on 2026-09-15 at the statement source"The authors have stated explicitly that there are no conflict of interests in connection with this article."RCT · probiotics · 41 patients / 90 days · mixed · basis: funding statementmixed
CNPq (grant); DuPont Danisco (donated the probiotics)basis: funding statement
checking-supplement-sciencedo-oral-probiotics-work
In silico modelling to differentiate the contribution of sugar frequency versus total amount in driving biofilm dysbiosis in dental cariesHead D, 2017, Sci RepDOI PubMed Statement sourceLedger id HEAD2017laboratorysugar— (computational model)
Acknowledgements: "This work was funded by the School of Computing, University of Leeds, United Kingdom and the School of Dentistry, University of Leeds, United Kingdom. The views expressed are those of the authors and not necessarily…
Acknowledgements: "This work was funded by the School of Computing, University of Leeds, United Kingdom and the School of Dentistry, University of Leeds, United Kingdom. The views expressed are those of the authors and not necessarily those of the funding bodies."Read on 2026-09-16 at the statement source
"The authors declare that they have no competing interests."laboratory · sugar · — (computational model) · public/charity · basis: funding statementpublic/charity
University of Leeds (School of Computing and School of Dentistry)basis: funding statement
can-teeth-remineralise
Chlorhexidine mouthrinse as an adjunctive treatment for gingival healthJames P, 2017, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id J2017systematic reviewmouthwash51 studies, 5,345 participants
4 weeks to 6 months
"Internal sources: Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, UK. External sources: Health Research Board Cochrane…
"Internal sources: Division of Dentistry, School of Medical Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, UK. External sources: Health Research Board Cochrane Fellowship Scheme, Ireland. National Institute for Health Research (NIHR), UK. This project was supported by the NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health. The views and opinions expressed herein are those of the review authors and do not necessarily reflect those of the Systematic Reviews Programme, the NIHR, the NHS or the Department of Health. Cochrane Oral Health Global Alliance, Other. The production of Cochrane Oral Health reviews has been supported financially by our Global Alliance since 2011 (oralhealth.cochrane.org/partnerships-alliances). Contributors over the past year have been the American Association of Public Health Dentistry, USA; the British Association for the Study of Community Dentistry, UK; the British Society of Paediatric Dentistry, UK; the Canadian Dental Hygienists Association, Canada; the Centre for Dental Education and Research at All India Institute of Medical Sciences, India; the National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and NHS Education for Scotland, UK."Read on 2026-09-15 at the statement source
"As former Director of the Oral Health Services Research Centre, Cork, Helen Whelton has conducted clinical trials of products for GlaxoSmithKline (GSK) and she received consultancy fees in relation to this research. Mairead Harding…
"As former Director of the Oral Health Services Research Centre, Cork, Helen Whelton has conducted clinical trials of products for GlaxoSmithKline (GSK) and she received consultancy fees in relation to this research. Mairead Harding (Deputy Director of the Oral Health Services Research Centre) was involved in the development of educational materials with regard to tooth wear/dental erosion and has conducted epidemiological studies and presented the findings on tooth wear and dental erosion at conferences. Fees received from GlaxoSmithKline for this work were paid to the Oral Health Services Research Centre, Cork and not to Mairead Harding. Philip Riley is a salaried member of the Cochrane Oral Health editorial team. Editorial control of the review and final decisions about the content of the review were maintained by Helen Worthington who is Co-ordinating Editor of Cochrane Oral Health. The remaining co-authors declare no conflict of interest."
systematic review · mouthwash · 51 studies, 5,345 participants / 4 weeks to 6 months · public/charity · basis: funding statementpublic/charity
NIHR, via Cochrane Infrastructure funding to Cochrane Oral Health; Health Research Board, Irelandbasis: funding statement
is-mouthwash-bad-for-you
Timing of dietary acid intake and erosive tooth wear: a case-control studyO’Toole S, 2017, J DentDOI PubMed Statement sourceLedger id OTOOLE2017case-controlerosion
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)case-control · erosion · — · not stated · basis: none availablenot stated
not statedbasis: none available
enamel-erosion-causes
Effect of oil pulling in promoting oro dental hygiene: a systematic review of randomized clinical trialsGbinigie O, 2016, Complement Ther MedDOI PubMed Statement sourceLedger id OP2016systematic reviewoil pulling5 trials, 160 participants
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: University of Oxford, Centre for Evidence-Based Medicine, Nuffield Department of Primary Care Health Sciences, New Radcliffe House, Radcliffe Observatory Quarter, Oxford OX2 6GG, United Kingdom. (record)systematic review · oil pulling · 5 trials, 160 participants · not stated · basis: none availablenot stated
not statedbasis: none available
oil-pulling-does-it-work
Evaluation of the efficacy of potassium nitrate and sodium fluoride as desensitizing agents during tooth bleaching treatment—A systematic review and meta-analysisWang Y, 2015, J DentDOI PubMed Statement sourceLedger id WANG2015meta-analysiswhiteningRCTs (number not given in the abstract)
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan 430079, China. | The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China; Department of Prosthodontics, School and Hospital of Stomatology, Wuhan University, 237# Luo Yu Road, Wuhan 430079, China. Electronic address: dryizhou@whu.edu.cn. | Indiana University School of Dentistry, Indianapolis, IN, USA. (record)meta-analysis · whitening · RCTs (number not given in the abstract) · not stated · basis: none availablenot stated
not statedbasis: none available
do-whitening-strips-damage-enamel
Desensitizing toothpaste versus placebo for dentin hypersensitivity: a systematic review and meta-analysisBae JH, 2015, J Clin PeriodontolDOI PubMed Statement sourceLedger id BAE2015meta-analysissensitivity31 RCTs
Conflict of interest and source of funding statement: "The authors declare that there are no conflicts of interest in this study. No external funding was available for this study."Read on 2026-09-23 at the statement sourceConflict of interest and source of funding statement: "The authors declare that there are no conflicts of interest in this study. No external funding was available for this study."meta-analysis · sensitivity · 31 RCTs · none declared · basis: funding statementnone declared
none declaredbasis: funding statement
sensitive-teeth-toothpaste
Xylitol-containing products for preventing dental caries in children and adultsRiley P, 2015, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id R2015systematic reviewxylitol10 studies, 5,903 participants
varied; the toothpaste trials ran about 3 years
"Internal sources: The University of Manchester, UK. Manchester Academic Health Sciences Centre (MAHSC), UK. The Cochrane Oral Health Group is supported by MAHSC and the NIHR Manchester Biomedical Research Centre. External sources:…
"Internal sources: The University of Manchester, UK. Manchester Academic Health Sciences Centre (MAHSC), UK. The Cochrane Oral Health Group is supported by MAHSC and the NIHR Manchester Biomedical Research Centre. External sources: National Institute for Health Research (NIHR), UK. The NIHR is the largest single funder of the Cochrane Oral Health Group. Disclaimer: The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR, NHS or the Department of Health. Cochrane Oral Health Group Global Alliance, Other. The production of all our reviews is assisted by funding from our Global Alliance partners (http://ohg.cochrane.org/): British Association for the Study of Community Dentistry, UK; British Association of Oral Surgeons, UK; British Orthodontic Society, UK; British Society of Paediatric Dentistry, UK; British Society of Periodontology, UK; Canadian Dental Hygienists Association, Canada; Mayo Clinic, USA; National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Royal College of Surgeons of Edinburgh, UK."Read on 2026-09-15 at the statement source
"There are no financial conflicts of interest and the review authors declare that they do not have any associations with any parties who may have vested interests in the results of this review."systematic review · xylitol · 10 studies, 5,903 participants / varied; the toothpaste trials ran about 3 years · public/charity · basis: funding statementpublic/charity
NIHR and the Cochrane Oral Health Group Global Alliancebasis: funding statement
can-teeth-remineralisexylitol-for-teeth
Powered versus manual toothbrushing for oral healthYaacob M, 2014, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id Y2014systematic reviewelectric toothbrush56 trials, 5,068 participants
1 to 3 months and longer
"Internal sources: School of Dentistry, The University of Manchester, UK. School of Dentistry, The University of Birmingham, UK. Edinburgh Dental Institute, UK. University of Sheffield, School of Dentistry, UK. MAHSC, UK. The Cochrane Oral…
"Internal sources: School of Dentistry, The University of Manchester, UK. School of Dentistry, The University of Birmingham, UK. Edinburgh Dental Institute, UK. University of Sheffield, School of Dentistry, UK. MAHSC, UK. The Cochrane Oral Health Group is supported by the Manchester Academic Health Sciences Centre (MAHSC) and the NIHR Manchester Biomedical Research Centre. External sources: Cochrane Oral Health Group Global Alliance, UK. All reviews in the Cochrane Oral Health Group are supported by Global Alliance member organisations (British Association of Oral Surgeons, UK; British Orthodontic Society, UK; British Society of Paediatric Dentistry, UK; British Society of Periodontology, UK; Canadian Dental Hygienists Association, Canada; Mayo Clinic, USA; National Center for Dental Hygiene Research & Practice, USA; New York University College of Dentistry, USA; and Royal College of Surgeons of Edinburgh, UK) providing funding for the editorial process (http://ohg.cochrane.org/). National Institute for Health Research (NIHR), UK. CRG funding acknowledgement: The NIHR is the largest single funder of the Cochrane Oral Health Group. Disclaimer: The views and opinions expressed therein are those of the authors and do not necessarily reflect those of the NIHR, NHS or the Department of Health."Read on 2026-09-15 at the statement source
"Bill Shaw and Helen Worthington were co-researchers on a randomised controlled trial sponsored by Braun AG (Clerehugh 1998) through a grant to The University of Manchester. Damien Walmsley was a consultant and undertook laboratory trials…
"Bill Shaw and Helen Worthington were co-researchers on a randomised controlled trial sponsored by Braun AG (Clerehugh 1998) through a grant to The University of Manchester. Damien Walmsley was a consultant and undertook laboratory trials of powered toothbrushes sponsored by Braun AG through a grant to the University of Birmingham."
systematic review · electric toothbrush · 56 trials, 5,068 participants / 1 to 3 months and longer · public/charity · basis: funding statementpublic/charity
NIHR and the Cochrane Oral Health Group Global Alliancebasis: funding statement
electric-vs-manual-toothbrush
Effectiveness of arginine-containing toothpastes in treating dentine hypersensitivity: a systematic reviewSharif MO, 2013, J DentDOI PubMed Statement sourceLedger id SHARIF2013systematic reviewsensitivity
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: School of Dentistry, University of Manchester, Manchester, United Kingdom. mohammad.sharif@manchester.ac.uk (record)systematic review · sensitivity · — · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste
Instant dentin hypersensitivity relief of a single topical application of an in-office desensitizing paste containing 8% arginine and calcium carbonate: a split-mouth, randomized-controlled studyKapferer I, 2013, Acta Odontol ScandDOI PubMed Statement sourceLedger id KAPFERER2013RCTsensitivity30 subjects, 60 teeth
12 weeks
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceDeclaration of interest: "The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper."Affiliations on PubMed: Department of Restorative and Operative Dentistry, Dental School, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria. ines.kapferer@gmx.net (record)RCT · sensitivity · 30 subjects, 60 teeth / 12 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste
Evaluation of the plaque removal efficacy of a water flosser compared to string floss in adults after a single useGoyal CR, 2013, J Clin DentPubMed Statement sourceLedger id G2013RCTwater flosser70 adults
single use
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: BioSci Research Canada Ltd., Mississauga, Ontario, Canada. (record)RCT · water flosser · 70 adults / single use · not stated · basis: none availablenot stated
not statedbasis: none available
do-water-flossers-work
Physiological role for nitrate-reducing oral bacteria in blood pressure controlKapil V, 2013, Free Radic Biol MedDOI PubMed Statement sourceLedger id KAPIL2013cohortmouthwash19 healthy volunteers
7-day control period, 7-day mouthwash period
Acknowledgments: "This work forms part of the research themes contributing to the translational research portfolio of the National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts and the London School of…
Acknowledgments: "This work forms part of the research themes contributing to the translational research portfolio of the National Institute for Health Research Cardiovascular Biomedical Research Unit at Barts and the London School of Medicine and Dentistry. V.K., V.P., and this work are supported by the British Heart Foundation. J.O.L. and E.W. have received grants from the Swedish Heart–Lung Foundation, Torsten and Ragnar Söderberg Foundation, Vinnova (CIDaT), and EU’s 6th Framework Program (Flaviola). A.A., J.O.L., and E.W. are all directors of Heartbeet Ltd."Read on 2026-09-16 at the statement source
No statement in the papercohort · mouthwash · 19 healthy volunteers / 7-day control period, 7-day mouthwash period · public/charity · basis: funding statementpublic/charity
British Heart Foundation; NIHR Cardiovascular Biomedical Research Unit (per the acknowledgments)basis: funding statement
is-mouthwash-bad-for-you
Brushing force of manual and sonic toothbrushes affects dental hard tissue abrasionWiegand A, 2013, Clin Oral InvestigDOI PubMed Statement sourceLedger id WG2013laboratoryelectric toothbrush27 volunteers (brushing force); specimens (abrasion)
Acknowledgements: "The authors wish to thank all volunteers for their participation in the study. We also thank the companies Biomed AG, Switzerland and Procter & Gamble GmbH, Germany, for providing the toothbrushes."Read on 2026-09-16 at the statement source"The authors declare that they have no conflicts of interest."laboratory · electric toothbrush · 27 volunteers (brushing force); specimens (abrasion) · not stated · basis: none availablenot stated
not stated (Biomed AG and Procter & Gamble provided the toothbrushes, per the acknowledgements)basis: none available
electric-vs-manual-toothbrush
The effect of different interdental cleaning devices on gingival bleedingRosema NA, 2011, J Int Acad PeriodontolPubMed Statement sourceLedger id ROSEMA2011RCTwater flosser108 adults
4 weeks
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Department of Periodontology, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, The Netherlands. (record)RCT · water flosser · 108 adults / 4 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
do-water-flossers-work
Instant dentin hypersensitivity relief of a new desensitizing dentifrice containing 8.0% arginine, a high cleaning calcium carbonate system and 1450 ppm fluoride: a 3-day clinical study in Chengdu, ChinaFu Y, 2010, Am J DentPubMed Statement sourceLedger id FU2010RCTsensitivity122 subjects
single application, then 3 days
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: The Key State Laboratory of Oral Diseases, Sichuan University, Chengdu, China. (record)RCT · sensitivity · 122 subjects / single application, then 3 days · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpastesensitive-teeth-causes
The human oral microbiomeDewhirst FE, 2010, J BacteriolDOI PubMed Statement sourceLedger id D2010narrative reviewmicrobiome
Acknowledgments: "This work has been supported in part by contract U01 DE016937 and grants DE015847 and DE017106 from the National Institute of Dental and Craniofacial Research and a supplement to grant DE016937 from the American Recovery…
Acknowledgments: "This work has been supported in part by contract U01 DE016937 and grants DE015847 and DE017106 from the National Institute of Dental and Craniofacial Research and a supplement to grant DE016937 from the American Recovery and Reinvestment Act of 2009."Read on 2026-09-16 at the statement source
No statement in the papernarrative review · microbiome · — · public/charity · basis: funding statementpublic/charity
National Institute of Dental and Craniofacial Research (per the acknowledgments)basis: funding statement
oral-microbiome
Effect of a dental water jet with orthodontic tip on plaque and bleeding in adolescent patients with fixed orthodontic appliancesSharma NC, 2008, Am J Orthod Dentofacial OrthopDOI PubMed Statement sourceLedger id SH2008RCTwater flosser106 adolescents
4 weeks
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: BioSci Research Canada Ltd., Mississauga, Ontario, Canada. (record)RCT · water flosser · 106 adolescents / 4 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
do-water-flossers-work
The erosive potential of flavoured sparkling water drinksBrown CJ, 2007, Int J Paediatr DentDOI PubMed Statement sourceLedger id B2007laboratoryerosion
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: School of Dentistry, University of Birmingham and Birmingham Dental Hospital, Birmingham, UK. (record)laboratory · erosion · — · not stated · basis: none availablenot stated
not statedbasis: none available
enamel-erosion-causes
Potassium containing toothpastes for dentine hypersensitivityPoulsen S, 2006, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id POULSEN2006systematic reviewsensitivity6 trials in the meta-analysis
6 to 8 weeks
"Internal sources: Royal Dental College, Faculty of Health Sciences, University of Aarhus, Denmark. External sources: No sources of support supplied"Read on 2026-09-23 at the statement source"One of the review authors, Sven Poulsen (SP), was rewarded a prize from Zendium Inc., Denmark in 1997."systematic review · sensitivity · 6 trials in the meta-analysis / 6 to 8 weeks · public/charity · basis: funding statementpublic/charity
Royal Dental College, University of Aarhus (internal source)basis: funding statement
sensitive-teeth-toothpaste
Tongue scraping for treating halitosisOuthouse TL, 2006, Cochrane Database Syst RevDOI PubMed Statement sourceLedger id O2006systematic reviewtongue scraping2 trials, 40 participants
single sessions; withdrawn by Cochrane in 2016
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)systematic review · tongue scraping · 2 trials, 40 participants / single sessions; withdrawn by Cochrane in 2016 · not stated · basis: none availablenot stated
not statedbasis: none available
tongue-scraping
Comparison of irrigation to floss as an adjunct to tooth brushing: effect on bleeding, gingivitis, and supragingival plaqueBarnes CM, 2005, J Clin DentPubMed Statement sourceLedger id BARNES2005RCTwater flosser105 enrolled, 95 completed
28 days
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: UNMC College of Dentistry, Lincoln, NE, USA. (record)RCT · water flosser · 105 enrolled, 95 completed / 28 days · not stated · basis: none availablenot stated
not statedbasis: none available
do-water-flossers-work
Brushing abrasion of softened and remineralised dentin: an in situ studyAttin T, 2004, Caries ResDOI PubMed Statement sourceLedger id ATTIN2004in situerosion
Statement not readable (paywalled)Read on 2026-09-16 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Department of Operative Dentistry, Preventive Dentistry and Periodontology, Georg August University Göttingen, Göttingen, Germany. (record)in situ · erosion · — · not stated · basis: none availablenot stated
not statedbasis: none available
enamel-erosion-causes
Supragingival calculus: formation and controlJin Y, 2002, Crit Rev Oral Biol MedDOI PubMed Statement sourceLedger id JY2002narrative reviewcalculus
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)narrative review · calculus · — · not stated · basis: none availablenot stated
not statedbasis: none available
48-hoursplaque-vs-tartar
The optimum time to initiate habitual xylitol gum-chewing for obtaining long-term caries preventionHujoel PP, 1999, J Dent ResDOI PubMed Statement sourceLedger id H1999cohortxylitol288 children re-examined
5 years after a 2-year gum programme
Statement not readable (paywalled)Read on 2026-09-15 at the statement sourceStatement not readable (paywalled)cohort · xylitol · 288 children re-examined / 5 years after a 2-year gum programme · not stated · basis: none availablenot stated
not statedbasis: none available
xylitol-for-teeth
Dentine hypersensitivity and the placebo response. A comparison of the effect of strontium acetate, potassium nitrate and fluoride toothpastesWest NX, 1997, J Clin PeriodontolDOI PubMed Statement sourceLedger id WEST1997RCTsensitivity120 subjects, 112 completed
6 weeks
Statement not readable (paywalled)Read on 2026-09-23 at the statement sourceStatement not readable (paywalled)Affiliations on PubMed: Department of Restorative Dentistry (Periodontology), Bristol Dental School, UK. (record)RCT · sensitivity · 120 subjects, 112 completed / 6 weeks · not stated · basis: none availablenot stated
not statedbasis: none available
sensitive-teeth-toothpaste

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Cite this dataset

Archived on Zenodo with a DOI: 10.5281/zenodo.22879103 · this snapshot: v1, 21 September 2026, 68 papers.

Pollman J. Trial funding ledger: funding and competing-interest statements for oral-health trials, reviews and guidelines. Zenodo; 2026. doi:10.5281/zenodo.22879103

@dataset{pollman_trial_funding_ledger_2026,
  author    = {Pollman, Jose},
  title     = {Trial funding ledger: funding and competing-interest statements for oral-health trials, reviews and guidelines},
  year      = {2026},
  publisher = {Zenodo},
  version   = {1},
  doi       = {10.5281/zenodo.22879103},
  url       = {https://doi.org/10.5281/zenodo.22879103}
}

The live table above may run ahead of the archived snapshot; the snapshot is the citable version.

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How to read a funding statement

The commonest sentence in the table is a version of “the funder had no role in study design, data collection, analysis or the decision to publish”. It tells you something real: the sponsor did not sit in the analysis. It does not tell you who chose the comparator, the outcome or the non-inferiority margin, and those are decided before a trial starts, when the funder is very much in the room. Read it as a statement about the middle of a trial, not the beginning.

Author employment is a different disclosure from sponsorship, and the ledger keeps the two apart. A trial paid for by a company is one thing; a trial with company employees on the author list is another, and a paper can be both. Look for the initials in a competing-interests line — “JE, FM and ESc are employees of” — and then look at the author list of the systematic review that later pools the trial. The site’s own worked example is hydroxyapatite: three of the four human trials name the same manufacturer as funder or employer, and the review that pools them shares every one of its six authors with the 18-month trial it includes. The ledger shows that as two rows — P2023 and PW2024 — and the pattern is the point.

The absence of a statement is information too. A paper from 2013 with no funding line may simply predate the journal’s policy; a paper from 2019 without one is a choice. We record the absence as a literal — “No funding statement in the paper” — rather than guessing, and we record a paywall as a paywall. A sponsor-funded trial whose funding line we could not read is not evidence of anything except that we could not read it.

What this ledger cannot tell you

Funding is not fraud. Manufacturer-funded trials in this table were, as far as the abstracts and papers show, competently run; some are the only trials of their kind. Unfunded trials can be small, short and badly blinded, and several of the papers with “none declared” are exactly that. The ledger records disclosure, not quality; the quality is argued page by page, in the articles that cite each paper, with the trial’s own numbers. Nor does the ledger rank anything: the rows sort by year, topic or funder type, and that is all the ordering there is. Where a statement stayed unreadable it is a fact about publishing, not about the paper: the journals concerned are Acta Odontol Scand, Am J Dent, Am J Orthod Dentofacial Orthop, Caries Res, Cochrane Database Syst Rev, Complement Ther Med, Crit Rev Oral Biol Med, Evid Based Dent, Int J Paediatr Dent, J Breath Res, J Clin Dent, J Clin Periodontol, J Dent, J Dent Res, J Evid Based Dent Pract, J Int Acad Periodontol, whose full text sits behind a paywall or behind a site that refuses automated reading.

How a paper gets in

Someone opens the paper. The funding statement and the competing-interests statement are copied word for word, in quotation marks. Where they were read and the date they were read on are recorded with them. Nothing is paraphrased and nothing is guessed, which is why a statement behind a paywall is recorded as a paywall rather than filled in.

The data file, its fields and the five fixed phrases are documented in the field guide.

Reuse the data

trials.json is published under CC BY 4.0: copy it, build on it, credit Know Your Mouth. The quoted statements remain the words of their authors and journals. Nothing you do on this page is sent anywhere; the table is plain HTML and the search runs in your browser.

This is a record of what papers disclose about their funding, not advice about any product or treatment. Nothing here is medical or dental advice; see a dentist about your own teeth.